人肝癌裸鼠移植模型的研究进展  

Research progress of human hepatocellular carcinoma models in nude mice

作　　者：叶翩[1] 张淑玲[1] 揭盛华[1] 董继华[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院感染科,湖北省武汉市430030

出　　处：《世界华人消化杂志》2006年第36期3500-3503,共4页World Chinese Journal of Digestology

摘　　要：肝癌的基础与临床研究迫切需要能真正模拟肝癌在人体内自然生长、侵袭及转移全部过程的动物模型.目前,人肝癌裸鼠移植模型是人体外最接近人类肝癌的整体实验模型,并且造模时间短,成功率高,按移植部位可以分为皮下移植、原位移植、腹腔移植以及转移模型.影响裸鼠移植模型建立的因素主要有人肝癌细胞或外科标本的特性、移植部位及移植癌细胞数量、裸鼠的品系和周龄以及生长环境和其他因素的影响.Animal models, which can factually simulate the natural growth, invasion, and metastasis in vivo, are needed in basic and clinical research on liver cancer. At present, nude mice with transplanted human hepatocellular carcinoma are the best models of human liver cancer in vitro, and it takes less time to establish the model, with a higher success rate. Mouse model of human hepatocellular carcinoma can be obtained by subcutaneous transplantation, in situ transplantation, and intraperitoneal transplantation. Metastasis model was also one of them. The following aspects, including the characteristics of human hepatocellular carcinoma cells or surgical specimens, transplanted location, numbers of the transplanted cells, strains and week age of nude mice, and growing environment, etc, are the influential factors for the establishment of this model.

关 键 词：肝癌 裸鼠 移植 模型 

分 类 号：R735.7[医药卫生—肿瘤]