宫颈细胞涂片中的非典型鳞状细胞与低度鳞状上皮内病变  

Atypical squamous cells and lower-grade squamous intraepithelial lesions in cervical cytological smear

作　　者：张新莹[1] 郭东辉[1] 张小晶[1] 赵文海[1] 

机构地区：[1]天津市中心妇产科医院病理科,天津300052

出　　处：《诊断病理学杂志》2006年第6期407-409,I0007,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨宫颈细胞学涂片中非典型鳞状细胞(ASC)与低度鳞状上皮内病变(LSIL)的状况与意义。方法对439例ASC与LSIL病变进行回顾性分析,其中163例进行了组织学诊断对照,47例进行了HPV原位杂交检测。结果ASC与LSIL占同期子宫颈细胞学涂片的2·42%,组织学证实的高级别病变在ASC-US、ASC-H和LSIL中分别占18·68%、33·3%与16·7%,>40%的ASC与LSIL病例高危HPV(+)。结论ASC中包括较多高级别病变,在ASC与LSIL病例中有相当比例的高危HPV感染。Objective To investigate the status and significance of the atypical squamous cells （ASC） and lower-grade squamous intraepithelial lesions （LSIL） in cervical cytological smear. Methods 439 cases of ASC and LSIL were analyzed retrospectively, in which the results were eomparied with the histological diagnosis in 163 cases, and the HPV status were detected by in situ hybridization techniques in 47 cases. Results The ratio of the ASC and LSIL was 2.42%. The higher grade lesions were proved in the 18.68% of ASG-US, 33.3% of ASC-H and 16.7% of LSIL respectively by the histological examination. More than 40% cases of ASC and LSIL were positive for high grade type of HPV. Conclusion Some high grade cases may be hided in ASC, and HPV infection with high-risk type is not rare in both ASC and LSIL.

关 键 词：宫颈细胞学 非典型鳞状细胞 低度鳞状上皮内病变 

分 类 号：R737.33[医药卫生—肿瘤]