Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients  

作　　者：Roberto Herrera-Goepfert Jesús K Yamamoto-Furusho Luis F Oate-Ocaa Margarita Camorlinga-Ponce Leopoldo Muoz Jorge A Ruiz-Morales Gilberto Vargas-Alarcón Julio Granados Cellular Biology Section 

机构地区：[1]Department of Pathology, Institute Nacional de Cancerologia (INCan), Mexico City, Mexico [2]Department of Immunology and Rheumatology, Institute Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico Department of Gastroenterology, Institute Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico [3]Department of Gastroenterology (INCan), Mexico City, Mexico [4]Medical Research Unit on Infectious and Parasitic Diseases, Hospital de Pediatria, Centro Medico Nacional Siglo XXI (CMN-SXXI), Institute Mexicano del Seguro Social (IMSS), Mexico City, Mexico [5]Department of Immunology and Rheumatology, Institute Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico [6]Department of Physiology, Institute Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico

出　　处：《World Journal of Gastroenterology》2006年第48期7762-7767,共6页世界胃肠病学杂志（英文版）

基　　金：Supported in part by Consejo Nacional de Ciencia y Tecnologiagrant, Mexico, No. 153237

摘　　要：AIM： To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma.METHODS： Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosorbent assay （EUSA） method. RESULTS： We found a significant increased frequency of HLA-DQBI＊0401 allele in Hpylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P = 1 × 10^-7, odds ratio （OR） = 4.96; 95% confidence interval （95% CI）, 3.87-6.35]. We also found a significant increased frequency of HLA-DQBI＊0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals （P = 1 × 10^4, OR = 13.07; 95% CI, 2.82-85.14）.CONCLUSION： HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and difffuse-type gastric adenocarcinoma in the Mexican Mestizo population.AIM: To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. METHODS: Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosor-bent assay (ELISA) method. RESULTS: We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P= 1 × 10-7, odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 × 10-6, OR = 13.07; 95% CI, 2.82-85.14). CONCLUSION: HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population.

关 键 词：HLA-DQ HLA-DQ5 HLA-DQBI＊0501 Hpy/or/ Chronic gastritis Gastric cancer Diffuse-type adenocarcinoma 

分 类 号：R573.3[医药卫生—消化系统] R735.2[医药卫生—内科学]