高强度聚焦超声联合乳化碘油损伤不切肋骨山羊肝脏组织的实验研究  

Combination of HIFU Radiated Ablation and Iodinated Lipid Emulsion Injection to Injure Normal Goat Liver Tissue in Vivo Without Costab Bone Incision

作　　者：肖雁冰[1] 刘丽萍[1] 肖子文[1] 王智彪[1] 李发琪[1] 王燕芹[1] 

机构地区：[1]重庆医科大学超声工程研究所,重庆市400016

出　　处：《中国超声医学杂志》2007年第1期15-18,共4页Chinese Journal of Ultrasound in Medicine

基　　金：国家杰出青年基金资助项目(No.30325027);教育部创新团队项目(教技函No.[2005]33);重庆市自然科学基金项目(渝科发计字No.[2004]47)

摘　　要：目的探讨高强度聚焦超声(HIFU)损伤不切肋骨山羊肝脏组织的可行性。方法31只羊随机分成两组,实验组经静脉注入乳化碘油,用HIFU对肝脏进行辐照,比较坏死组织体积、能效因子、靶区灰度及组织病理检查。对照组以normalsaline代替乳化碘油,余步骤同实验组。结果两组损伤组织均为凝固性坏死。实验组损伤率、靶区灰度阳性率分别为71.1%和26.8%,对照组分别为16.3%和4.1%(P<0.05)。结论乳化碘油可增强HIFU的损伤效果,通过一定的手段实现在不切肋骨条件下对肝脏组织的HIFU损伤是可行的。Objective The purpose of this study was to explore the feasibility of ablating goat liver using HIFU and a self-made iodinated lipid emulsion （SMILE） through intercostal spaces. Methods Thirty-one goats were randomly divided into two groups. SMILE was injected intravenously into goats in the experimental （Ex） group. Goats＇ livers were exposed to HIFU through the intercostal spaces half an hour after SMILE was injected intravenously. The enhanced gray scale in target region was real-time recorded. The sizes of the lesions were measured and energy efficiency factors were calculated after experiment. Tissues at the lesion boundary were sampled for histological examination. All procedures were the same as those for the Ex group except that SMILE was replaced with normal saline in the control （con） group. Results Typical necrosis occurred in the target issues. The necrosis rates were 71. 1% and 16.3% in Ex and con groups respectively（P〈0.01）. Conclusions Necrosis rate of goats liver may be increased by HIFU combined with SMILE. It may be reliable to ablate liver tissue in large animals using HIFU combined with some approaches through the intercostal spaces.

关 键 词：乳化碘油 高强度聚焦超声 肋骨 羊肝脏 

分 类 号：R735.7[医药卫生—肿瘤]