肝癌筛检间隔确定———嵌套病例对照研究  

Determination of Screening Interval for Liver Cancer :A Nested Case-Control Study

作　　者：周小平 陈启光 恽振先[1] 沈其君[1] 张宏[1] 陈建国 张宝初 朱源荣 王墨荣 姜允辉 

机构地区：[1]南京铁道医学院卫生统计学教研室 [2]启东肝癌研究所

出　　处：《南京铁道医学院学报》1996年第4期226-228,共3页Journal of Nanjing Railway Medical College

基　　金：国家自然科学基金

摘　　要：目的：利用肝癌周期性筛检资料，确定筛检间隔。方法：嵌套病例对照研究。结果：经一次ＡＦＰ阴性筛检，ＯＲ值下降为基准的１０％左右；连续两次阴性和连续三次阴性其ＯＲ值相差不大；一次阴性筛检后，其ＯＲ值迅速下降，随着时间推移，其保护效应逐渐减少，１．５ａ左右保护效益基本消失。Objective :To try to determine the periodic screening interval for liver cancer.Method :The nested casecontrol studies were used.Result :After a negative screening test,the OR declines to about one tenth as before.The OR value after two continuous negative screening tests is similar to that after three continuous negative tests.On TSLT,the results show that the risk for liver cancer drops after a negative test.As time elapsed,the OR rises gradually,and its protective effect against liver cancer will disappear after 1.5a.Conclusion :It is suggested that the appropriate screening interval for high risk population of liver cancer be a year.

关 键 词：筛检间隔 LOGISTIC回归 肝癌 

分 类 号：R735.7[医药卫生—肿瘤]