急性白血病患者血清肿瘤坏死因子α的检测及临床意义  

MEASUREMENT OF SERUM TUMOUR NECROSIS FACTOT-ALFA AND ITS CLINICAL SIGNIFICANCE IN ACUTE LEUKEMIA PATIENTS

作　　者：李大启[1] 杨金平[1] 王占聚[1] 李公宝[1] 王宝珍[2] 胡美玉[2] 

机构地区：[1]潍坊医学院附院内一科,261031 [2]上海医科大学中山医院

出　　处：《潍坊医学院学报》1996年第4期267-269,共3页Acta Academiae Medicinae Weifang

摘　　要：为探讨肿瘤坏死因子α(TNF-α)在急性白血病(AL)中的作用,用双抗体夹心ELISA法测定56例初诊AL患者及40例正常人血清TNF-α水平,并对不同病期的AL患者进行动态观察.发现AL患者血清TNF-α水平显著高于正常对照组(P<0.01),化疗后7～12d,化疗敏感组ANLL患者血清TNF-α水平显著低于化疗前(P<0.01),难治性急性非淋巴细胞白血病(ANLL)患者血清TNF-α持续在高水平.AL患者达完全缓解(CR)时,血清TNF-α含量接近正常.结果提示,血清TNF-α的检测有助于观察AL的病情变化,并可作为预测ANLL疗效的早期指标.To explore the value of tumour necrosis factor -alfa(TNF -α)in acute leukemia, the levels of serum TNF -αwere detected in 56 newly diagnosed acute leukemia patients and 40 normal controls by sandwich ELISA methods. Meanwhile, the serum TNF -α levels were serially measured along with their clinical course. The results showed the levels of TNF -αin acute leukemia patients were significantly higher than that of controls (P<0. 001). Serum TNF -α levels in responsive group with acute myeloid leukemia (AML) was significantly decreased after 7 to 12 days through chematherapy (P<0 .01) ,but that of refractory group kept high. The levels of TNF -α were near normal when the patients received complete remission. It suggested a good correlation between the TNF -α levels and desease activity. Serum TNF -α could be used as an early indicator to predict the clinical response in AML patients.

关 键 词：急性白血病 肿瘤坏死因子Α 血清 

分 类 号：R733.71[医药卫生—肿瘤]