出血性脑卒中出血灶IL-1、IL-6、IL-8的动态变化  

Dynamic changes of inflammatory in hematoma fluid of intracerebral hemorrhage

作　　者：梁艺华[1] 叶俭[1] 任宁毅[1] 

机构地区：[1]广西医科大学附属肿瘤医院核医学科,广西南宁530021

出　　处：《中国基层医药》2006年第12期1945-1946,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察出血性脑卒中患者血肿灶IL-1、IL-6、IL-8的动态变化。方法以行微创颅内血肿清除术100例中、重度(出血量>30 ml)高血压脑出血患者为研究对象,连续监测血肿冲洗液中IL-1、IL-6、IL-8的动态变化。结果高血压脑出血发病6-12 h血肿冲洗液中即已检测出IL-1、IL-6、IL-8,在出血急性期呈现不同变化趋势。结论高血压脑出血后IL-1、IL-6、IL-8等炎性细胞因子参与了其后的病理过程,其水平变化与疾病的转归有关。Objective To investigate the dynamic changes of inflammatory cytokines IL-1, IL-6 and IL-8 in hematoma after hypertensive cerebral hemorrhage and the clinical significance. Methods Data of hematoma fluid from 100 patients with severe hypertensive cerebral hemontage（blood loss 〉 30ml） undergoing minimally invasive evacuation of intracranial hematoma in our department were analyzed retrospectively. The chants of IL-1, IL-6 and IL-8 in hematoma fluid were observed continuously. The content of IL-1, IL-6 and IL-8 was determined by radioimmunassay. Results IL-1, IL-6 and IL-8 were observed at 6 - 12h after hypertensive cerebral hemorrhage, and showed different changes in acute stage. Conclusion Inflammatory cytokines are involved in the pathological process of cerebral hemorrhage.

关 键 词：脑血管意外 白细胞介素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]