非小细胞肺癌中FHIT、cyclinD_1、CDK_4的表达及意义  

The expression of FHIT,CyclinD1,CDK4 and their signicance in NSCLC

作　　者：郭妍妍[1] 

机构地区：[1]内蒙古医学院第一附属医院儿科,内蒙古呼和浩特010059

出　　处：《中国基层医药》2006年第12期1994-1995,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的研究非小细胞肺癌(NSCLC)中脆弱性组氨酸三联体(FHIT)、细胞周期素D1(cyclinD1)、细胞周期蛋白依赖激酶4(CDK4)的表达与NSCLC发生发展的关系。方法采用免疫组化(S-P)法检测NSCLC标本81例。结果FHITc、yclinD1、CDK4在正常组织及NSCLC中的表达差异有统计学意义(均P<0.05)。FHIT表达与分化程度有相关性(P<0.01)。cyclinD1、CDK4表达与TNM分期相关(P<0.01,P<0.05)。FHIT-、cyclinD1+、CDK4+组与FHIT+、cyclinD1-、CDK4-组相比,在正常组织与NSCLC中表达有差异(P<0.05),且与分化程度及TNM分期有相关性。结论FHITc、yclinD1、CDK4是非小细胞肺癌发生发展的分子机制之一;联合分析FHIT、cyclinD1、CDK4比单独应用各指标对研究NSCLC的发生发展更有价值。Objective To investigate the role of FHIT,cyclinD1 ,CDK4 in NSCLC. Methods Immunochemical（S-P） was used to determined 81 cases of NSCLC. Results The postive expression rates of FHIT, cyclinD1 , CDK4 were significantly different between in NSCLC and in nomal lung tisses （P 〈 0.05 ）. The expression rates of FHIT were correlated with degree of differentiation of NSCLC（ P 〈 0.01 ）. The expression rates of cyclinD1 and CDK4 had the relativity with TNM stage（P 〈 0.05, P 〈 0.01）. The expression rate of the group of FHIT^-, cyclinD1^＋ ,CDK4^＋ was significantly higher in NSCLC than in the nomal lung tisses（P 〈 0.05） and the group had ralitivity with the degreee of differention of NSCLC,TNM stage. Conclusions FHIT,cyclinD1 ,CDK4 are one of events in NSCLC. Multi-factor analysis of FHIT, cyclinD1 ,CDK4 is more important than sigle-factor analysis.

关 键 词：癌 非小细胞肺 脆弱性组氨酸三联体 细胞周期素D1 细胞周期蛋白依赖激酶4 

分 类 号：R734.2[医药卫生—肿瘤]