DNA拓扑异构酶与抗肿瘤  

DNA topoisomerase and antitumor

作　　者：莫晓媚[1] 李静[1] 耿美玉[1] 

机构地区：[1]中国海洋大学医药学院分子药理室,山东青岛266003

出　　处：《中国药理学通报》2007年第1期20-23,共4页Chinese Pharmacological Bulletin

基　　金：国家重点基础研究发展规划(973规划)资助项目(No2003CB716400)

摘　　要：DNA拓扑异构酶是真核细胞和原核细胞中的基本酶,广泛分布于细胞核内,在复制、转录、翻译、重组及染色体单体分离等过程中控制、维持和修饰DNA拓扑结构。研究发现,拓扑异构酶在肿瘤组织中高表达,许多抗肿瘤药物的作用机制与抑制拓扑异构酶有关。DNA topoisomerase is a basic enzyme in eucaryon and prokaryotic cells, which distributes in cell nucleus generally. DNA topoisomerase plays important roles in the process of duplication, transcription, translation, recombination and chromosome monomer isolation to control, keep and modify the DNA topology. It is reported that DNA topoisomerase has a high expression level, which related with the mechanism of many antitumor drugs.

关 键 词：DNA拓扑异构酶 抗肿瘤 不典型多药耐药 

分 类 号：R-05[医药卫生] R73