心气虚证大鼠模型心功能变化的超声评价  

Echocardiography evaluation about the heart function change on rat models of heart-Qi deficiency syndrome

作　　者：金红姝[1] 林水淼[2] 杨戈[3] 郁志华[2] 张钦传 

机构地区：[1]辽宁中医药大学,辽宁沈阳110032 [2]上海中医药大学老年医学研究所,上海200032 [3]北京西苑医院,北京100019 [4]临沂市卫生局,山东临沂276003

出　　处：《山东中医药大学学报》2007年第1期75-77,共3页Journal of Shandong University of Traditional Chinese Medicine

基　　金：国家自然基金重点资助项目(编号:39830450)

摘　　要：目的:应用高频超声心动图观察心气虚证模型大鼠心功能的变化,探索心气虚证动物模型非损伤式心功能评价手段。方法:将SD雄性大鼠随机分为4组,分别为正常组、D-半乳糖组(D-gal)、心气虚组、D-半乳糖+心气虚组,采用多次少量放血加大剂量灌服心得安的方法制作心气虚证动物模型,行经胸超声心动图检测。结果:心气虚模型组、D-gal+心气虚组大鼠左室射血分数(EF)、左室短轴缩短率(FS)均明显降低(P<0.05),左室收缩功能明显下降。结论:应用超声心动图能准确评价心气虚证模型大鼠心功能的变化。Objective： Applied with echoeardiography to observe the heart function change of heart-Qi deficiency rat. To investigate a non-injury means for the heart fimction evaluation on the animal models of heart-Qi deficiency. Methods： 36 SD rats were divided randomly. The rat models with heart Qi deficiency were established by repeated bloodletting in small amount and large dose propranolol taken orally, and then detected by echocardiography. Results： The ejection fraction and fraction shortening of the rat models were significantly decreased （P 〈 0.05）, and its left ventricular systolic function was descendants distinctly. Conclusion： Echocardiography can be used accurately to evaluate the heart function change of heart-Qi deficiency rat.

关 键 词：心气虚证 大鼠 心功能 超声心动图 

分 类 号：R228[医药卫生—中医基础理论]