卵磷脂和氢化卵磷脂长循环阿霉素脂质体的制备及缓释研究  

Study on the Prepapation and Slow Release of the EPC and HEPC Doxorubicin Liposomes

作　　者：于美丽[1] 王勇[2] 舒贵明[1] 朱争艳[1] 方叔昌[1] 王黎[1] 

机构地区：[1]天津市第三中心医院肝胆疾病研究所,天津300170 [2]天津复印技术研究所,天津300130

出　　处：《北京生物医学工程》2006年第6期654-657,共4页Beijing Biomedical Engineering

基　　金：天津市卫生局科研基金(99KY007)资助

摘　　要：采用薄膜超声法制备卵磷脂(EPC)和氢化卵磷脂(HEPC)长循环阿霉素脂质体,研究比较EPC和HEPC长循环阿霉素脂质体在大鼠体内释药的差异,选择良好的靶向性药物载体。用高效液相色谱法研究EPC和HEPC长循环阿霉素脂质体在大鼠体内的药物动力学。大鼠体内药物动力学研究结果表明,HEPC长循环阿霉素脂质体在血中平均驻留时间(MRT)为23.3h,EPC长循环阿霉素脂质体在血中MRT为12.0h。HEPC长循环阿霉素脂质体是更好的靶向性药物载体。To study the preparation and slow release of EPc and HEPC doxonabicin liposomes, choosing a better carrier in delivering the drugs, the pharmacokinetics of EPC and HEPC sterically stabilized liposomes （EPC-SSL, and HEPC-SSL） were studied by HPLC. studies on pharmacokinetics showed that the mean residence time （MRT） of HEPC-SSL in blood is 23.3h, while MRT of EPC.SSL is 12.0h, and the area under the curve （AUC） of concentration of HEPC-SSL is larger than that of EPC-SSL. Conclusion HEPC-SSL is a better carrier in delivering the drugs to the extravascular sites than EPC-SSL.

关 键 词：卵磷脂 氢化卵磷脂 阿霉素 药物动力学 

分 类 号：R318.08[医药卫生—生物医学工程]