HRT对生育期妇科恶性肿瘤患者生活质量的影响  

THE EFFECT OF HRT TO QOL OF THE WOMEN WITH GYNECOLOGIC CANCER IN BEARING PERIOD

作　　者：潘忠勉[1] 李力[1] 陈心秋[1] 黄丽[1] 高琨[1] 

机构地区：[1]广西医科大学附属肿瘤医院妇瘤科,南宁530021

出　　处：《广西医科大学学报》2006年第6期921-923,共3页Journal of Guangxi Medical University

基　　金：广西科技厅科技攻关课题资助(No.桂科攻9817101)

摘　　要：目的:探讨卵巢功能去势后的生育期妇科恶性肿瘤患者采用激素替代治疗(HRT)是否可改善其生活质量(QOL)。方法:采用EORTC-C30量表和自制的特异性量表对生育期宫颈癌62例[HRT组中宫颈癌31例,非激素替代治疗(NHRT)组中宫颈癌31例],卵巢恶性肿瘤52例(HRT组中卵巢恶性肿瘤26例和NHRT组中卵巢恶性肿瘤26例)及77例正常绝经的妇女进行问卷评分,评价HRT对妇科恶性肿瘤患者在术后或放疗后卵巢功能去势后的QOL的影响。结果:①EORTC-C30量表的功能子量表评分方面,HRT组的身体功能、情绪功能和NHRT组的比较差异有统计学意义(P<0·05)(HRT组评分较低,则其QOL较高);症状子量表评分方面,HRT组和NHRT组评分比较差异亦有统计学意义(P<0·05)(HRT组评分较低,症状轻,则其QOL较高)。在总体健康情况和总生命质量评分中,HRT组和NHRT组比较差异亦有统计学意义(P<0·05)(HRT组评分高,QOL较高)。②自制的特异性量表中,性生活、植物神经功能失调评分方面,HRT组和NHRT组比较差异亦有统计学意义(P<0·05)(HRT组评分低,QOL较好)。结论:HRT能在某种程度上改善生育期妇科恶性肿瘤患者术后或放疗后的QOL。Objective. To explore whether HRT can improve the QOL in women with gynecologic malignancy. Methods. 62 women with cervical cancer, 52 patients with ovarian cancer in bearing period after surgery or radiotherapy and 77 women in normal menopause were studied（HRT was used in 31 women with cervical cancer and 26 women with ovarian cancer after surgery or radiotherapy, the other women didn＇t use HRT）. The EORTC-C30 list and special list the which was made by us were used to analyze the effect of HRT to these women＇s QOL. Resuit：（1）In EORTC-C30 list there was significant difference（ P 〈0.05） in body function and emotion function between HRT and NHRT groups in the function branch list （The grade of HRT group was lower than that of NHRT group. The QOL of HRT group was better）. There was significant difference（ P 〈0.05） in symptom branch list between HRT and NHRT groups （The grade of HRT group was lower than that of NHRT group. The symptom of HRT group was lighter and their QOL was better）. In the grade of total wealth and QOL, there was significant difference （ P 〈0.05） between HRT and NHRT group （the grade of HRT group was higher and the QOL of HRT group was better）. （2） In the special list made by us, there was significant difference（ P 〈0.05） between HRT and NHRT group in the grade of sex quality and autonomic nerve malajustment （The grade of HRT group was lower and the QOL of HRT group was better）. Conclusion. HRT can improve QOL of the women with gynecologic cancer in bearing period after surgery or radiotherapy in a way.

关 键 词：妇科恶性肿瘤 激素替代治疗 生活质量 

分 类 号：R737.3[医药卫生—肿瘤]