肺癌p16蛋白表达缺失及其意义  

THE ROLE OF PRA, AⅡ,ALD,ANP AND EDF IN DEVELOPMENT OF HIGH ALTITUDE PULMONARY EDEMA

作　　者：姜彦多[1,2] 王永信[1,2] 何安光 王继红[1,2] 王晓牧[1,2] 

机构地区：[1]解放军第202医院 [2]中国医科大学肿瘤研究所

出　　处：《解放军医学杂志》1996年第6期437-438,共2页Medical Journal of Chinese People's Liberation Army

摘　　要：用免疫组织化学方法观察了ｐ１６蛋白在肺癌和癌旁正常组织的表达。结果ｐ１６蛋白在良、恶性细胞中均有表达，癌旁正常支气管粘膜上皮细胞和浆液腺ｐ１６蛋白的阳性率高于癌组织（Ｐ＜０．０１）。肺癌组织ｐ１６蛋白在阳性率为６６．１％，腺癌高于鳞癌（Ｐ＜０．０１）。在鳞癌和腺癌ｐ１６蛋白的阳性率随着分化程度的降低而下降，高分化和低分化腺癌之间ｐ１６阳性率的差别有显著性意义（Ｐ＜０．０５）。Ⅰ～Ⅱ期鳞癌ｐ１６的阳性率高于Ⅲ～Ⅳ期鳞癌（Ｐ＜０．０５）。结果表明，ｐ１６蛋白表达缺失与肺癌的发生有关，随着分化程度的降低和肿瘤的进展表达缺失增加。Plasma levels of PRA,AⅡ,ALD,ANP and serum level of EDF were determined in 40 patients with high altitude pulmonary edema(HAPE) by radioimmunoassay and compared with those in 40 patients with high altitude acute response (HAAR) and 40 healthy subjects as controls.All of them arrived recently in Ihasa,a place with an altitude of 3658m.It was found that PRA,AⅡ,ALD,ANP and EDF were significantly higher in patients with HAAR and HAPE than those in the controls.The important role of these bioactive substances in the the development of HAPE was discussed.

关 键 词：肺肿瘤 基因表达 免疫学 P16蛋白 

分 类 号：R734.2[医药卫生—肿瘤]