Endoglin在皮肤血管瘤中的表达及其与TGF-β1的关系  

Expression of Endoglin in Human Dermal Hemangioma and Correlation Between Survivin and TGF-beta1

作　　者：叶玲[1] 陕声国[1] 魏翠娥[1] 张端莲[2] 

机构地区：[1]武汉大学人民医院整形外科,湖北武汉430060 [2]武汉大学医学院人体解剖与组织胚胎学系,湖北武汉430071

出　　处：《武汉大学学报（医学版）》2007年第1期58-61,I0003,共5页Medical Journal of Wuhan University

基　　金：国家自然科学基金资助项目(编号:30271345)

摘　　要：目的:研究Endoglin在各期血管瘤组织中的表达情况、与转化生长因子-β1(TGF-β1)的关系。方法:随机选取51例血管瘤病例(增生期29例、退化期22例)和5例正常皮肤组织,用免疫组化方法分别显示Endoglin、TGF-β1在组织中的表达情况,并运用病理图像分析软件分析它们的表达差异和关系。结果:Endoglin在增生期血管瘤组织的新生毛细血管中有较强表达(光密度值和阳性面积率分别为0.219 0±0.009 0、0.119 5±0.034 7),而在退化期血管瘤和正常皮肤组织中表达较弱(分别为0.123 5±0.005 9、0.057 8±0.018 8;0.122 9±0.004 6、0.057 2±0.017 5),有显著统计学差异(P<0.01)。TGF-β1在退化期血管瘤组织中的表达明显强于增生期和正常皮肤组织,具有显著性差异(P<0.01)。Endoglin和TGF-β1在血管瘤不同时期中的表达具有负相关性。结论:Endoglin在增生期血管瘤组织中有异常高表达,且其表达异常在血管瘤的病理发展中有着重要作用。Objective. To investigate the expression of Endoglin in the two stages of hemangioma and the correlation between Endoglin and TGF-1 and explore the role of Endoglin for the pathogenesis of hemangioma. Methods： Fifty-one cases of human dermal hemangioma and five cases of normal skin were were involved and analyzed for the expression of Endoglin and TGF- 1 by immunochemistry. Results： The positive ratio and average light density of Endoglin were obvious higher in proliferative hemangioma（0. 219 0±0. 009 0,0. 119 5±0. 034 7）than those in involutional hemangioma（0. 123 5±0. 005 9,0. 057 8±0.018 8）and normal skin（0. 122 9±0. 004 6,0. 057 2±0. 017 5） with significant difference（P〈0.01）. The average light density of TGF-β1 in involutional hemangioma was 0. 151 7±0. 014 0, which was higher than that in proliferative hemangioma and normal skin tissues. Analysis of data also showed that there＇s a negative correlation between the expression of Endoglin and TGF- β1 （r=- 0. 62, P〈0.01）. Conclusion： It can be deduced that there is an intimate relationship between the Endoglin and the pathogenesis of hemangioma.

关 键 词：ENDOGLIN 转化生长因子-Β1 血管瘤 免疫组化 

分 类 号：R732.2[医药卫生—肿瘤]