HIF-1α P-gp在腋淋巴结阴性乳腺癌组织中的表达及意义  

Expression of HIF-1α and P-gp in Axillary Node-Negative Breast Carcinoma

作　　者：马超[1] 周庚寅[1] 肖颖 高鹏[1] 郭玲玲[1] 林晓燕[1] 

机构地区：[1]山东大学齐鲁医院耳鼻喉研究所齐鲁医院病理科,济南市250012 [2]齐鲁大学医学院分子医学实验室

出　　处：《中国肿瘤临床》2007年第1期10-13,共4页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金资助(编号:30300124)

摘　　要：目的:检测缺氧诱导因子-1α(HIF-1α)、P-糖蛋白在腋淋巴结阴性乳腺癌组织中的表达情况及其与乳腺癌分型、分级及预后的关系。方法:采用免疫组织化学方法检测81例乳腺癌和20例癌旁组织中HIF-1α、P-gp的表达状况,分析与各临床病理因素和预后的关系。结果:HIF-1α在乳腺癌中总阳性表达率为69.1%,其中强表达10例(12.3%),中度表达12例(14.8%),弱表达34例(42.0%),隐性25例(30.9%);81例乳腺癌组织中34例P-gp表达阳性,占42.0%,其中强表达7例(8.6%),中度表达9例(11.1%),弱表达18例(22.2%),阴性47例(58.0%)。HIF-1α和P-gp在乳腺癌中两者阳性指数呈正相关(r=0.62,P<0.01)。HIF-1α为单独影响乳腺癌预后的危险因素。结论:HIF-1α和P-gp两者阳性指数在乳腺癌中呈正相关;HIF-1α可作为判断乳腺癌恶性程度、预后的单独指标,高表达者5年生存率低,检测HIF-1α有助于提高评估腋淋巴结阴性乳腺癌术后生存的准确性。Objective： To study the expression of HIF-1α and P-gp in breast cancer and to determine the correlation with prognosis. Methods： Formalin-fixed, paraffin-embedded samples from 81 breast cancer patients were tested for HIF-1α and P-gp expression by immunocytochemical staining. Then the influence of these expression levels on the clinical and pathological parameters and on survival was investigated. Results： Strong expression of HIF-1α was observed in 10 cases （12.3%）, while expression was moderate in 12 cases （14.8%） and weak in 34 cases （42.0%）. No expression was found in 25 cases （30.9%）. Strong expression of P-gp was observed in 7 cases （8.64%）, moderate expression was observed in 9 cases （11.1%） and weak expression was observed in 18 cases （22.2%）. No expression was found in 47 cases （58.0%）. HIF-1α expression had a significant positive correlation with the expression of P-gp （r=0.62, P〈0.01）. In the 64 cases with follow-up data, univariate analysis revealed that the survival rate was correlated with histological grading, staging, tumor size, and expression of HIF-1α and P-gp. However, Cox stepwise proportional hazards analysis showed that only HIF-1α was considered independently significant for predicting patient outcome. Conclusions： The expression of P- gp may be correlated with HIF-1α expression. HIF-1α expression is correlated with the prognosis of breast carcinoma. The expression of HIF-1α can be used to accurately assess the prognosis in breast carcinoma and may be helpful for evaluating the prognosis of ANNBC.

关 键 词：乳腺肿瘤 缺氧诱导因子 P糖蛋白 预后 

分 类 号：R737.9[医药卫生—肿瘤]