口腔颌面部肉瘤组织中hTERT和Ki-67蛋白的表达  

Expression of hTERT and Ki-67 in oromaxillofacial sarcoma tissue

作　　者：王海斌[1] 赵军方[1] 李新明[1] 李峰[1] 

机构地区：[1]郑州大学第一附属医院口腔颌面外科,郑州450052

出　　处：《郑州大学学报（医学版）》2007年第1期70-72,共3页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省医学科技创新人才基金资助项目200311229

摘　　要：目的:检测口腔颌面部肉瘤组织中端粒酶逆转录酶(hTERT)和Ki-67蛋白的表达。方法:应用免疫组化方法检测37例口腔颌面部肉瘤组织和14例良性间叶组织肿瘤和3例正常组织中hTERT和Ki-67蛋白的表达。结果:正常组织中hTERT、Ki-67不表达。口腔肉瘤组织中hTERT蛋白的阳性表达率为51.4%,明显高于良性肿瘤的7.1%(P<0.05)。口腔颌面部肉瘤组织中Ki-67LI为30.88%,明显高于良性肿瘤组织的4.44%(P<0.01)。hTERT蛋白阳性表达肉瘤组织中Ki-67LI明显高于hTERT蛋白阴性表达的肉瘤组织(P<0.01)。结论:hTERT基因激活和细胞增殖在口腔间叶组织细胞实现永生化、发生恶变的过程中可能起重要作用。Aim： To investigate the expression of hTERT and Ki-67 protein in oromaxillofacial sarcoma （OMFS） tissue. MethOdS： The expression of hTERT and Ki-67 protein was detected in 37 cases of OMFS, 14 benign mesenchymal tumor tissue and 3 cases of normal tissue using immunohistochemistry. Results： There was no hTERT or Ki-67 positive expression in normal tissue, hTERT positive expression rate was 51.4% in OMFS tissue and 7.1% in benign tumor, and a significant diffenence was found between the 2 groups （P 〈0. 05 ）. Ki-67 proliferation index （LI） in OMFS tissue was significantly higher than that in benign tumor tissue （P 〈 0. 01 ）. Ki-67 LI in hTERT-positive OMFS tissue was higher than that in hTERT-negative tissue （P 〈 0. 01 ）. Conclusion ： hTERT activation coupling with cell proliferation may play an important role during the course of immortalization and carcinogenesis of OMFS.

关 键 词：口腔颌面部肉瘤 端粒酶逆转录酶 KI-67 

分 类 号：R739.8[医药卫生—肿瘤]