宫颈小细胞癌的临床病理分析  

Clinicopathological study of small cell carcinoma of the cervix

作　　者：曲渊[1] 张彤[1] 姜智[2] 徐新宇[1] 莫伏根[1] 

机构地区：[1]江苏省肿瘤医院病理科,江苏南京210009 [2]江苏省肿瘤医院妇瘤科,江苏南京210009

出　　处：《医学研究生学报》2007年第1期46-48,I0012,共4页Journal of Medical Postgraduates

基　　金：江苏省科委社会发展基金项目(批准号:BS2000069)

摘　　要：目的:探讨宫颈小细胞癌临床病理特点。方法:复习7例宫颈小细胞癌的临床病理资料、苏木精-伊红(H-E)染色切片及免疫组化标记,对其中4例行血管内皮生长因子(VEGF)免疫组化标记。结果:7例患者平均年龄为37岁,主要症状为不规则阴道流血。镜下瘤细胞呈雀麦形或中间型。3例分别伴有鳞状细胞癌、子宫内膜样腺癌及低分化腺癌成分,免疫组化表达神经内分泌分化,表达VEGF。按FIGO临床分期为Ⅰb期2例、Ⅱ期2例、Ⅲ期2例,1例病期不清。5例获得随访,除1例无瘤生存(39个月)外,其余4例均死亡。结论:宫颈小细胞癌极具侵袭性,进展快,死亡率高。Objective：To study the clinical and pathological features of small cell carcinoma of cervix . （SCCC）. Methods：Clinical data, pathological changes and immunohistochimical findings were reviewed in 7 cases of small cell cervical carcinoma （SCCC）, and immunohistochemical staining was performed for VEGF in 4 cases of SCCC. Results：The average age was 37 years in 7 patients, and the main symtoms were vaginal bleeding. Under microscope, tumor cells showed oat or intermediate cell type, Three tumors were associated with other forms of carcinoma ： squamous cell carcinoma, endometrial carcinoma, poor-differentiated adenocarcinoma. Immunohistochemical staining showed neuroendocrine differentiation and VEGF. Their FIGO staging was stage Ⅰb in 2 cases, stage Ⅱ in 2 cases, stage Ⅲ in 2 cases. In the 5 patients with follow-up data, 4 were dead and 1 was in following up. Conclusion： Small cell carcinoma of the cervix has stated an extremely aggressive biological behavior with minimal survival chances and a rapid and fatal clinical course.

关 键 词：宫颈小细胞癌 免疫组织化学 血管内皮生长因子 

分 类 号：R737.33[医药卫生—肿瘤]