MMP-2、MMP-7蛋白在胃癌组织中表达的意义  

The significance of MMP-2 and MMP-7 protein expression in human gastric carcinoma

作　　者：潘留兰[1] 鲍晓蕾[1] 陈永胜[1] 王艳芬[1] 娄燕[1] 

机构地区：[1]吉林大学第二医院,吉林长春130041

出　　处：《中国实验诊断学》2007年第1期84-86,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨基质金属蛋白酶MMP-2、MMP-7在胃癌组织中的表达、侵袭及转移的关系。方法应用免疫组化SP法检测87例胃癌组织、癌旁组织及正常胃组织中MMP-2、MMP-7的表达情况。结果MMP-2、MMP-7在正常胃组织表达率为阴性,在癌旁组织中有低表达,分别为18.4%、21.8%,在胃癌组织中表达率明显增高,且表达率的高低与淋巴结转移、分化程度、浸润程度呈密切相关性(P<0.05)。且MMP-2、MMP-7在胃癌组织中表达具有相关性。结论MMP-2、MMP-7在胃癌组织中的高表达且两者呈正相关,并对胃癌的预后判定有一定意义。Objective To study the significance of MMP-2、MMP-7 protein expression and the relationship with invasion、 differentiation and and metastasis in human gastric carcinoma.Methods MMP-2.MMP-7 expression were examined by irrxnunobistochemical S-P staining method in 87 cases of human gastric carcinoma、para-carcinoma and normal fissue.Results MMP-2、MMP-7 were negtive d in the nomud tissue, and low expession in para-carcinorna, respectively 18. 4 % 、21.8%. The overexpression of MMP-2、 MMP-7protein were found in gastric carcinoma,and the expression was highly related with lymphonode metastasia 、differentiation and invasion degree（P 〈 0.05）.Conclusion MMP-2.MMP-7 were highly expressed in gastric carcinoma, and the expressiion of MMP-2 was significantly correlated with MMP-7. Expression of MMP-2,MMP-7 is strongty associated with turnout progression, differentiation and and lymphonode metastasia in gastric cancer. Therefore MMP-2 ,MMP-7 may be clinlcally useful as predictor of patients survival.

关 键 词：胃癌 MMP-2 MMP-7 

分 类 号：R735.2[医药卫生—肿瘤]