人肝癌细胞系HepG2在遗传毒物检测中的应用及其进展  

Application of human hepatoma cell line HepG2 and its progress in the detection of genotoxicants

作　　者：姚晓峰[1] 仲来福[1] 

机构地区：[1]大连医科大学毒理学研究室,辽宁省大连市116027

出　　处：《世界华人消化杂志》2007年第2期145-150,共6页World Chinese Journal of Digestology

摘　　要：外来化合物的体外遗传毒性实验常用于各种致癌物和致突变物的快速筛选.HepG2是一种分化好的人肝胚细胞瘤细胞系,保留了较完整的代谢酶及其活性.以HepG2细胞作为实验系统检测各种致癌及非致癌物,在多个观察终点均获得相应的阳性及阴性结果.Genotoxicity test is widely used in the detection of various carcinogens and mutagens. HepG2 is derived from human hepatoblastoma, and it retains the activities of drug-metabolizing enzymes. It has been demonstrated that various carcinogens can be detected in genotoxicity test with HepG2 cells at several endpoints, whereas negative results have been obtained with noncarcinogens.

关 键 词：人肝癌细胞系 HEPG2细胞系 遗传毒物 体外遗传毒性实验 

分 类 号：R735.7[医药卫生—肿瘤]