侵袭性NK细胞白血病1例报告并文献复习  

Agressive NK-Cell Leukemia:A Case Report and Literature Review

作　　者：杨丽云[1] 郑静晨[2] 丁琪[3] 孟文霞[4] 张文[4] 

机构地区：[1]武警总医院血液科,北京100039 [2]武警总医院总医院,北京100039 [3]武警总医院检验科,北京100039 [4]武警总医院门诊,北京100039

出　　处：《中国误诊学杂志》2007年第1期17-19,共3页Chinese Journal of Misdiagnostics

摘　　要：目的:提高对侵袭性NK细胞白血病的认识。方法:对1例侵袭性NK细胞(ANKL)白血病患者的临床资料进行分析,并复习国内外相关文献。结果:该病好发于中青年,病程短,进展快,平均生存期2个月;ANKL患者常表现为发热及肝、脾、淋巴结肿大;外周血、骨髓涂片大颗粒淋巴细胞增多;免疫表型CD 2(+),表面CD 3(-),胞质CD 3(+),CD 56(+),CD 57(-);TCR基因重排均为阴性;有EB病毒感染的证据;常见染色体异常;排除其他大颗粒淋巴细胞白血病。结论:ANKL是一种罕见病,恶性度高,预后极差。Objective：To improve the recognization of aggressive NK-cell leukemia（ANKL）. Method：The clinical datum of one case of aggressive NK-cell leukemia was analyzed and the related literature was reviewed. Results ：The disease was commonly seen in young and middle-aged people. The disease had an aggressive clinical course and the median overall survival time of patients was 2 months. The paitents often present with fever, hepatosplenomegly and lymphadenopathy;increasing large granular lymphocytes could be finded in bone marrow and blood ;immunophenotype：CD2 （＋） ,suffaceCD3（-） ,cytoplasmCD3 （＋） ,CDS6（＋） ,CD57（-） ;TCR genes rearrangement negative; EB virus antibody usually positive;chromosomal abnormality usuallly exist;exclusion of other disease with large granular lymphocyte. Conclusion ：ANKL is extremely rare and high grade malignancy,it carries a very poor prognosis.

关 键 词：白血病/诊断 白血病浸润 

分 类 号：R733.704[医药卫生—肿瘤]