冠心宁注射液中洋川芎内酯Ⅰ的快速鉴定  

Identification of senkyunolide I in Guanxinning Injection chromatographic fingerprint by GC-MS and HPLC-PDA-MS-MS

作　　者：金樟照[1] 向智敏[1] 祝明[1] 吴文军 龚青[1] 鲁敏[1] 

机构地区：[1]浙江省药品检验所,浙江杭州310004 [2]绍兴兰亭集团,浙江绍兴322300

出　　处：《中成药》2007年第1期75-78,共4页Chinese Traditional Patent Medicine

摘　　要：目的:鉴定冠心宁注射液(丹参、川芎)指纹图谱中-未知成分。方法:采用液相制备,气质联用和液相色谱/PDA/MS联用技术鉴定结果。结果:未知成分可能为洋川芎内酯Ⅰ。结论:只需要少量样品,通过各种色谱质谱联用技术可以较快速地对已知成分进行结构确证。AIM： To identify an unknown peak in Guanxinning Injection （ Radix et Rhizome Salviae Miltiorrhizae, Rhizoma Chuanxiong） chromatographic fingerprint. METHODS： The elution（44-46 min） separated and collected by HPLC was analyzed by GC-MS and HPLC-PDA-MS-MS. RESULTS： The unknown peak was corresponding to senkyunolidel I. CONCLUSION： It is quick method to identify the reported chemical in herbal medicine based on a small quantity of sample by GC-MS and HPLC-PDA-MS-MS.

关 键 词：冠心宁注射液 色谱指纹图谱 液相制备 气质联用 洋川芎内酯I 

分 类 号：R927.2[医药卫生—药学]