鼻咽癌原发灶热疗的临床与热剂量学研究  

Clinical and Thermal Dosage Study on Hyperthermia for Primary Nasopharyngeal Cancer

作　　者：钟强荣[1] 李楚玉[1] 吴敬波[1] 曾智帆 

机构地区：[1]中山医科大学肿瘤医院放疗科,广州市510060

出　　处：《中国康复》1996年第3期116-118,共3页Chinese Journal of Rehabilitation

摘　　要：运用2450和915MHz微波鼻咽腔内辐射器对肌肉体模和患者作鼻咽腔内加温,以及用8MHz射频对鼻咽部作体外电容式透热加温,通过液晶膜感温试验和抗电磁波干扰的多点测温结果分析认为①采用腔内加热法不管使用何种频率对鼻咽癌仍局限于腔内的原发灶热疗,具有一定的意义,其有效加温深度大约在粘膜下0.5至1cm左右。用915MHz比用2450MHz要稍深一些。对稍远离鼻咽腔的周围软组织浸润病灶加温则因热衰减快透深不够而升温不理想;②体外电容式透热加温则因骨骼的屏蔽使鼻咽腔内升温不理想,未能达到有效治疗温度,但不排除对周围软组织侵犯病例的治疗意义;③对几十例鼻咽癌腔内热疗患者观察(另文)和临床测温研究提示人鼻咽腔内的热耐受能力较强,一般可达50℃左右,患者感觉为温热感和轻微疼痛,耳内热痛感,少量病例有头晕或恶心症状均在停止加温后消失。到目前为止,并未发现热灼伤和不可逆的组织损害。A phantom and patients with primary nasopharyngeal cancer were heated by use of 2450 MHz and 915 MHz microwave intracavity irradiation, and 8 MHz external diathermy. Through liquid crystal temperature testing and multipoint measurement of temperature, it was suggested that: 1) Intracavity heating was limited in the original focus, effective depth of intracavity hyperthermia was about 0. 5~1cm under the mucous membrane (The depth with 915 MHz was slightly more than that with 2450 MHz). Temperature felldown quickly in the tissue deviating from nasopharynx. 2) As a result of bond shielding, diathermy could not achieve effective treatment temperature in the nasopharynx cave. However, it was significant for treating patients having cancer diffusion in the tissue around nasopharynx cavity. 3) It was endurable for about 50℃ in human nasopharynx cave and patients felt warm and slight pain, and pain sense in ears.

关 键 词：鼻咽肿瘤 热疗 热剂量学 

分 类 号：R739.630.5[医药卫生—肿瘤]