中山地区先天性甲状腺功能低下症筛查结果分析  

Analysis of Neonatal screening for congenital hypothyroidism in Zhongshan.

作　　者：姚英姿[1] 吴日然[1] 谭志伟[1] 杨孜[1] 单念忠[1] 

机构地区：[1]南方医科大学附属中山博爱医院新生儿筛查中心,广东中山市528403

出　　处：《中国优生与遗传杂志》2007年第1期83-84,98,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨中山地区先天性甲状腺功能低下症(Congen italHypothyroid ism,CH)的发病率及疗效观察。方法1998年11月~2006年4月年间采集95471名出生48h^72h后的新生儿足跟血3滴于滤纸血片上,采用时间分辨荧光免疫法检测血斑中促甲状腺激素(thyroid stimu lating hormone,TSH)值;可疑阳性者再召回取静脉血,采用化学发光法检测血清中T3、T4和TSH浓度;确诊为CH的患儿根据病情轻重,及时给予规范的治疗。结果筛查新生儿95471例,可疑阳性患儿350例,确诊40例,发病率1/2387,其中男性患儿17例,女性患儿23例,平均治疗50.2d后血清13、T4、TSH达到正常范围。结论中山地区CH发病率高于全国平均水平,早期用左旋甲状腺素片治疗CH效果满意。Objectives： To investigate incidence and therapy of Congenital hypothyroidism （CH） in Zhongshan, Methods ： Thyroid stimulating hormone （TSH） screening for CH was done from 1998 to 2006 in neonates of 48 - 72 hours age, Three drops of blood were taken from heels of newborns to the Filter papers, then the values of TSH were measured by time - resolved fluoroimmuno assay. Infants with elevated TSH level were recalled for tests of serumfi iodothyronine （T3）, thyroxine （T4） and TSH by chemiluminesence. The confirmed Infants with CH were treated immediately. Results： 95471 filter paper samples were tested. 350 Infants with CH were questioned and 40 Infants witll CH were confirmed （ 17 boys and 23 girls）, incidence of CH Was 1/2387 in Zhongshan. After 50,2 （range： 14 -156） days of treatment, the levels ofserum T3, T4 and TSH were normalized. Conclusion： The incidence of CH in Zhongshan is higher than the average level ofthe whole country. Early treatment of CH is satisfactory.

关 键 词：先天性甲状腺功能低下症 新生儿疾病筛查 促甲状腺激素 发病率 

分 类 号：R722.1[医药卫生—儿科]