SARS男性患者睾丸组织的病理改变  

Pathological changes of testis tissue in SARS patients

作　　者：祁丽花[1] 迟晓春[1] 徐健[1] 杨京京[1] 宫恩聪[2] 顾江[2] 

机构地区：[1]北京大学医学部组胚教研室,北京100083 [2]北京大学医学部病理教研室,北京100083

出　　处：《基础医学与临床》2007年第1期40-43,共4页Basic and Clinical Medicine

基　　金：国家高技术研究发展计划重点项目(2003AA208107)

摘　　要：目的研究严重急性呼吸综合征(SARS)男性患者睾丸组织的病理变化。方法对5例SARS死亡患者的睾丸组织进行常规组织学、TUNEL及免疫组化染色。结果5例SARS患者睾丸生精小管基膜增厚、纤维化,生精上皮坏死、脱落,睾丸中几乎未见精子。生精细胞凋亡大量增加(P<0.05),间质充血,睾丸组织中有明显的白细胞浸润。CD3+T淋巴细胞、CD68+巨噬细胞较对照组明显增多(P<0.05),并浸润到生精小管中。结论SARS导致男性患者并发睾丸炎。Ojective To study the pathological changes of testis tissue in SARS patients. Methods Tissue specimens were studied by HE staining、TUNEL and immunohistochemistry（IHC）. Results SARS patients showed that widespead ened basement germ cells destruction,few or no spermatozoon in the seminiferous epithelium and the lumen, thickmembrane, peritubular fibrosis, vascular congestion and leukocytes infiltration. The apoptotic seminiferous cells increased significantly（P 〈 0.05 ）. The numbers of CD3^＋T lymphocyte and CD68^＋ macrophage increased significantly in the interstitial tissue as compared with that of control group （ P 〈 0. 05 ）, and infiltration of both cell types was found in the tubules. Conclusion SARS caused orchitis.

关 键 词：严重急性呼吸综合征(SARS) TUNEL 睾丸 睾丸炎 

分 类 号：R361[医药卫生—病理学] R511.9[医药卫生—基础医学]