聚丙烯材料假发移植物的组织相容性及可移植假发的外观效果  

Histocompatibility and appearance of wig grafts made of polypropylene

作　　者：易斌[1] 胡志奇[1] 孙锡金[1] 黄世峰[1] 朱权[1] 周洪军[1] 侯春[1] 

机构地区：[1]南方医科大学南方医院整形外科,广东省广州市510515

出　　处：《中国组织工程研究与临床康复》2007年第4期621-624,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目的:以聚丙烯为基础材料制作假发移植物,通过动物实验观察其组织相容性及可移植假发的外观仿真效果。方法:实验于2005-08/2006-08在南方医科大学动物实验中心完成。运用聚丙烯材料设计并加工成侧面呈锯齿状锚刺,顶端固定假发的移植物。移植物主干和锚刺均使用医用聚丙烯单丝线(购自上海浦东金环医疗用品有限公司)制作;发束由单根或多根真人毛发或其他动物毛发组成,根部插在主干端头的埋入孔内,加压融合。取10只新西兰白兔(南方医科大学动物实验中心提供),每只白兔头皮采用毛囊单位移植技术,植入20根假发移植物,10只白兔头皮共移植200根。将10只白兔按随机数字表法分为两组,即大体观察组和组织学观察组,每组5只。大体观察组主要观察1年内移植物脱落情况并计数;组织学观察组分别于移植后第1周、第2周及其后1年内每个月在无菌条件下,每只兔分次采集包含有1根移植物的头皮组织条,进行组织学观察。结果:10只白兔全部进入结果分析,无脱失。①移植物的组织形态学观察结果:移植后1周移植物周围组织炎症反应轻微;移植后2周移植物周围有大量胶原纤维形成,炎症细胞局部稍有增多,移植物的主干和锚刺间已有胶原纤维长入;移植1个月后,成熟的纤维组织形成包膜于移植物及锚刺周围,无明显炎症反应。移植2个月后至1年,移植物周围组织无明显不良反应。②移植物脱落情况:5只白兔头皮共移植100根移植物。移植后第1周共脱落4根,第2周脱落2根,第3周￣第12个月无脱落,总结1年内脱落率为6%,并集中于最初2周。结论:以聚丙烯为基础材料的假发移植物可以较稳固地锚定于头皮,具有良好的组织相容性,可获得较佳仿真效果,是运用毛发修复外科技术治疗秃发的一种新的探索。但移植术后早期要注意保护创面,防止牵拉移植物。AIM： To study the histocompatibility of wig grafts made of polypropylene and its simulating effect in appearance. METHODS： The experiment was conducted in the Animal Experimental Center of Southern Medical University between August 2005 and August 2006, The polypropylene grafts were designed with tiny barbs that were spaced evenly apart on the lateral surface and with wig fixating on the tip. Monofilament silk of medical polypropylene was used as the transplant and barbs （bought from Shanghai Pudong Jinhuan Medical Co. Ltd.）, while the hair bunch were composed of human hairs or animal hairs. The root of hair was embedded sin the pores of bole ends to fuse through pressurization. Ten Zelanian rabbits （provided by the Animal Experimental Center of Southern Medical University） were selected to implant 20 wig grafts in each white rabbit＇s scalp with hair follicle unit transplantation technology. There are 200 totally in 10 white rabbit＇s scalp. Ten rabbits were randomly divided into two groups： Bulk observation group and histomorphology observation group, with 5 rabbits in each group. Animals in bulk observation group were counted of the shed grafts within one year, while animals in the histoorphology group underwent histological study of one scalp tissue slice including one graft of each rabbit under the condition of sterility respectively in the first week, the second week and each month of the first year. RESULTS： A total of 10 rabbits were involved in the analysis of results, and no one withdrew from the Study. ①Histomorphological observation of the transplant grafts： One week post＇transplant, a small quantity of inflammatory cell infiltrating into the perigraft tissue was found with peripheral vessels dilasting and engorging lightly and a little inflammatory reaction through the microscope. In two weeks post-graft, a great quantity of collagen fibers forming could be found with inflammatory cells partly increasing and collagen fibers infiltrating between trunks and barbs. In a month po

关 键 词：毛发 移植 秃发 外科学 聚丙烯类 

分 类 号：R73-35[医药卫生—肿瘤]