心血管系统内分泌研究进展  

Advances in Cardiovascular System Endocrine

作　　者：唐朝枢[1] 齐永芬[1] 

机构地区：[1]北京大学医学部生理学与病理生理学系,分子心血管学教育部重点实验室,北京100083

出　　处：《生理科学进展》2007年第1期19-24,共6页Progress in Physiological Sciences

基　　金："973"重大血管性疾病发病机制和防治的基础研究(2006CB503807);国家自然科学基金(30670847)资助课题

摘　　要：心脏和血管的各种细胞分泌的生物活性分子,在心血管系统的功能稳态中具有重要的调节作用。新的活性肽的发现不仅提高了人们对疾病的认识,而且以新的活性多肽为靶点防治心血管疾病可能具有广阔的临床应用前景。心血管系统分泌的活性多肽不仅种类繁多,而且功能复杂,其功能复杂性不仅与其受体和受体亚型的组织分布和表达有关,还与其基因转录的剪切方式有关。此外,活性多肽的功能多样性还与其前体来源的其他片段以及活性多肽对受体的多选择性有关。Bioactive substances secreted from various cells of heart and vessels play a very important role in functional homeostasis of cardiovascular system. Discoveries of new bioactive peptides not only boost the cognition of the diseases, but also have extensive chnically prospectives in preventing and treating cardiovascular diseases. Bioactive peptides secreted from cardiovascular system have both multiple forms and diverse functions. The functional complexities of peptides correlated with receptor, distribution and expression of receptor subtype, and splicing of gene. In additon, the muhifunctions of peptides are concerned with other fragments of the same peptide precursor, and with the choices of the same ligend for multiple receptors.

关 键 词：心脏 血管 内分泌 活性多肽 

分 类 号：R331[医药卫生—人体生理学]