老年脑梗死血清中微量元素水平与血脂相关性研究  

Correlations between blood trace elements and blood lipids in senile cerebral infarction patients

作　　者：薛慎伍[1] 郑虹[1] 张兆岩[1] 王辉[1] 王娜[1] 

机构地区：[1]济南军区总医院干部四科,济南250031

出　　处：《山西医科大学学报》2007年第1期48-50,共3页Journal of Shanxi Medical University

基　　金：济南军区总医院院长基金资助项目

摘　　要：目的观察42例老年脑梗死患者(A组)和27例健康对照组(B组)体内钙、锌、镁、铁、铜、镉、铅7种微量元素变化,探讨微量元素含量变化与脑梗死的发病机制及早期防治的关系。方法采用LK98B型微量元素自动分析仪,取指血测量A、B两组治疗前7种微量元素含量。结果A组Ca2+,Fe2+,Cr2+含量(分别为3.10,244.81,0.067μmol/L)高于B组(1.31,220.19,0.04μmol/L),P<0.05;而Zn2+,Mg2+,Cu2+,Pb2+含量(分别为97.52,1.51,16.31,9.12μmol/L)低于B组(116.32,1.85,19.00,11.37μmol/L),P<0.05。Logarithmic regression相关分析表明,胆固醇水平改变与Zn2+呈正相关,r=0.50,P<0.05;两组间载脂蛋白与Ca2+呈正相关,r=0.51,P<0.05。其他脂质类虽呈正负相关性,但无统计学意义。结论微量元素改变可使血脂代谢障碍,参与脑梗死形成机制,老龄人更应注意微量元素适量的补充。Objective To study the relations between trace dements and cerebral infarction pathogenesis and earlier prevention methods by observing changes of Ca^2＋ ,Zn^2＋ , Mg^2＋ , Fe^2＋ , Mg^2＋ , Cr^2＋ and Pb^2＋ in 42 patients with senile cerebral infarction （group A） and 27 normal senile controls. Methods Trace elements from finger blood were measured with trace element autoanalyzerof LK98Btype. Results The concentrations of Ca^2＋ ,Fe^2＋ and Cr^2＋ ingroupA（3.10,244.81, 0. 067 μmol/L） weresig- nificantly higher than that in group B （ 1.31,220.19 and 0.04 μmol/L）, P 〈 0.05. The concentrations of Zn^2＋ , Mg^2＋ , Cu^2 ＋ and Pb^2＋ in group A （97.52,1.51,16.32 and 9.12 μmol/L） were significantly lower than that in group B （ 116.32, 1.85, 19.00 and 11.37 μmol/L）, P 〈 0.05. The results showed that cholesterol level positively correlated with Zn^2 ＋ （ r = 0.50, P 〈 0.05 ）, and apolipoprotein level positively correlated with Ca^2＋ （ r = 0.51, P〈 0.05）. While other lipids showed no significant correlation with trace elements. Conclusion Trace elements can block the normal blood lipid metabolism, provoke the angiosclerosis, enhance the cerebral infarction development. Senile people should pay more attention to supplement of the trace elements.

关 键 词：脑梗死 痕量元素 高脂血症 

分 类 号：R743.32[医药卫生—神经病学与精神病学]