单剂量康泉与枢复宁预防腹腔内化疗所致胃肠道反应的疗效比较  

The effect of ondanstron and granistron of single dose to prevent the emesis and vomiting induced by intraperitoneal chemotherapy

作　　者：修元德[1] 于爱卿[1] 纪杲 王淑运 刘希光[1] 赵圆圆[1] 张滨[1] 刘华敏[1] 

机构地区：[1]青岛医学院附属医院,青岛市儿童医院,青岛建工医院

出　　处：《肿瘤防治研究》1996年第5期311-313,共3页Cancer Research on Prevention and Treatment

摘　　要：采用随机自身对比方法观察３６例应用和单剂量康泉（３ｍｇ）和单剂量枢复宁（８ｍｇ）预防腹腔内化疗所致胃肠道反应的效果。二者均在化疗前３０分钟静注一次，化疗方法均为ＰＤＤ６０－８０ｍｇ、５－Ｆｕ１０００－１５００ｍｇ、地塞米松１０－２０ｍｇ，一次腹腔内灌注。结果：康泉及枢复宁控制急性恶心有效率分别为９７．２％和９７．２％，没有差别（Ｐ＞０．０５），迟发性恶心ｄ２～ｄ５分别为９７．２％～１００．０％和９４．４％～１００．０％，亦无差别（Ｐ＞０．０５）；控制急性呕吐有效率分别为９７．２％和１００．０％，没有差别（Ｐ＞０．０５），迟发性呕吐ｄ２～ｄ５分别为９４．４％～１００．０％和９７．２％～１００．０％，亦无差别（Ｐ＞０．０５）；对改善进食各天均无差别。迟发性恶心发生率二者均为１１．１％，迟发性呕吐均为１３．９％。二者不良反应总发生率分别为３３．３％和３８．９％。结果显示单剂量康泉及枢复宁化疗前一次应用对预防腹腔化疗所致胃肠道反应的疗效均较好，且二者疗效及不良反应没有差别。The effect of ondanstron and granistron to prevent the emesis and vomiting induced by intraperitoneal chemotherapy was observed by randomized self-comparison.Both druge were administered at the time of 30 minutes before the start of chemotherapy.The results showed that the effective control rates of the acute emesis and vomiting by ondanstron and granistron were not different statistically(P>0.05)to delay emesis and vomiting, the effective control from day 2 to day 5 was also not of difference between the two drugs(P>0.05).The incidence of the side effect of the two drugs was 33.3% and 38.9%,respectively.Our conclusion was that the two drugs had no significane difference both in the prevention effect of emesis and vomiting induced by intraperitoneal chemotherapy and in the side effect.

关 键 词：康泉 枢复宁 治疗 腹腔内化疗 胃肠道反应 

分 类 号：R730.5[医药卫生—肿瘤]