吗丁啉预防化疗所致呕吐的临床研究  

The Effecacy of Domperidone as a Preventing Emetic Agnet in Chemotherapy-Induced Emeses

作　　者：陆禹溶[1] 陈嘉[1] 陆建伟[1] 成卫[1] 

机构地区：[1]江苏省肿瘤医院

出　　处：《肿瘤防治研究》1996年第4期242-244,共3页Cancer Research on Prevention and Treatment

摘　　要：吗丁啉为多巴胺－Ｄ２受体阻滞剂，极少中枢神经系统副作用。我们以口服负荷量加舌下含化维持量吗丁啉作为化疗呕吐的预防剂，对含中剂量ＤＤＰ（４０ｍｇ×３天）化疗方案呕吐的完全控制率为７４．３％，对不含ＤＤＰ化疗方案的呕吐完全控制率为８１．８％，同期枢复宁对合中剂量ＤＤＰ（４０ｍｇ×３天）化疗方案的呕吐完全控制率为７４．０％。本研究表明，吗丁啉预防化疗呕吐有效，无明显毒副作用，价廉，用法简便，值得进一步研究。Domperidone is a dopamin receptor blocker which is few adverses. Domperidone is admited by oral loaded dose and following by sublingual sustaining dose to prevert chemotherapy-induced emeses. The complete control rate of emese is 74.3% in containing MD-cisplatin regimens, 81.8% in containing middle-induced emeses agents and ondansetron is 74.0% in containgin MD-cisplatin regimens.Domperidone is not significant adverses and its expanse is much low.

关 键 词：化疗 并发症 呕吐 吗丁啉 完全控制率 药物疗法 

分 类 号：R730.53[医药卫生—肿瘤] R975.4[医药卫生—临床医学]