老年人卒中后抑郁与冠心病后抑郁的P300的对比研究  

A comparative study of P300 among old patients with post-stroke depression and post-coronary heart disease depression

作　　者：庞国防[1] 梁积英[1] 吕泽平[1] 胡才友[1] 潘文晶[1] 阳初玉[1] 

机构地区：[1]广西壮族自治区江滨医院,南宁530021

出　　处：《中国实用神经疾病杂志》2007年第1期19-21,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的应用P300对比研究老年人卒中与冠心病后有、无抑郁患者的认知功能损害。方法老年人卒中、冠心病后伴有抑郁患者分别为27例、31例;无抑郁患者分别为32例、28例;对照组为30名健康老年人。测定听觉事件相关电位P300的N1、P2、N2、P3成分。结果(1)与对照组比较:老年卒中后有、无抑郁组及老年冠心病后抑郁组P300潜伏期显著延长(P<0.05;P<0.01);老年卒中后抑郁组N2潜伏期显著延长(P<0.05);(2)老年冠心病后有、无抑郁组的P300潜伏期差异显著(P<0.05);(3)老年卒中后抑郁组比老年冠心病后抑郁组P300潜伏期显著延长(P<0.05);(4)与对照组比较:除冠心病后无抑郁组外,各试验组P3波幅显著降低(P<0.05)。结论老年人卒中后抑郁和冠心病后抑郁与认知功能损害有关;卒中后抑郁患者认知功能损害较冠心病后抑郁患者更明显;而老年卒中是认知功能损害的独立危险因素。Objective To explore cognitive function with P300 in depression and non-depression old patients with stroke and depression and non-depression in old patients with coronary heart disease. Methods The subjects included 27 depresed and 32 non depression patients with stroke ,31 depression and 28 non-depression in old patients with coronary heart disease, and 30 senile healthy controls. N1,P2, N2 and P3 components of P300 were recorded. Results （1）The latency of P3 in depression and non-depression in old patients with stroke and old patients with post-coronary heart disease depression, was longer than that in control group（P〈0.05 ;P〈0.01） , the latency of N2 in depression in old patients with stroke was longer than that in control group（P〈0.05） ; （2） The latency of P3 in old patients with post-coronary heart disease depression was longer than that in non-depression in old patients with coronary heart disease. （P〈0.05） ; （3） The latency of P300 in patients with post-stroke depression was longer than that in patients with post-coronary heart disease （P（0. 05） ;（4） Comparal with control group, the amplitrde of PS00 in other groups were reduced,except coronary heart group. Conclusions The results suggests that both patients with post-stroke depression and with post-coronary heart disease depression have cognitive impairment; cognitive impairment in old patients with post-stroke depression is more than that in post-coronary heart disease depression, stroke is independent risk factors associate with cognitive impairment.

关 键 词：老年 脑卒中 冠心病 抑郁 事件相关电位 

分 类 号：R749.13[医药卫生—神经病学与精神病学]