Ⅲ期食管癌几种不同分割模式照射的疗效观察  

Efficacy of stage Ⅲesophageal carcinoma treated by several fractionated radiotherapy

作　　者：盛延兴[1] 隋振忠[1] 郑芳霞[1] 尹爱芹[1] 张玉霞[1] 

机构地区：[1]山东省聊城市人民医院放疗科,252000

出　　处：《肿瘤研究与临床》2007年第1期25-26,29,共3页Cancer Research and Clinic

摘　　要：目的比较常规分割剂量每周照射7d，5d及后程加速超分割3种方法治疗Ⅲ期食管癌的疗效及放射反应。方法对138例首治Ⅲ期食管癌病例随机分成A、B、c组。A组46例，2．0Gy／次。5次／周，40—47d完成；B组46例，2．0Gy／次，7次／周，30～35d完成；C组46例，2．0Gy／次，5次／周，4周后，改为1．5Gy／次，2次／d，间隔6h以上，5次／周，35～40d完成。三组累积照射量均为60-70Gy。结果A、B、C组1年生存率分别为32．6％、67．4％、63．0％，3年生存率分别为6．5％、43．5％、41.3％，B、C组高于A组（P〈0．05）；1年局部控制率分别为34．8％、71．7％、69．6％，3年局部控制率分别为17．4％、56．5％、56．5％，B、C组高于A组（P〈0．05）；出血、穿孔的发生率分别为4．3％、6．5％、4．3％，3组间差异无统计学意义（P〉0．05）。结论常规分割剂量7d／周照射和后程加速超分割照射比5d／周照射可明显提高疗效。Objective To evaluate the effect of radiotherapy on stage Ⅲesophageal cancer with conventional fraction dose 7-day-per-week and 5-day-per-week and late course accelerated hyperfraction. Method From February 1999 to June 2002 138 patients with stage Ⅲesophageal cancer were divided into 3 groups： group A, B and C. Patients in the A group received a total dose of 60 - 70 Gy/30 - 35 fraction/40 - 47 days, and the B group received a total dose of 60 - 70 Gy/30-35 fraction/30 - 35 days, and the C group received a total dose of 60 - 70 Gy/34 - 40 fraction/37 - 40 days. Results The 1-year survival rates of the A, B, C group were 32.6 %, 67.4 %, 63.0 %（P 〈0.05）. The 1-year local tumor control rates of the three group were 34.8 %, 71.7 %, 69.6 %（P 〈0.05）. The 3-year survival rates of the A,B,C group were 6.5 %, 43.5 %, 41.3 %（P 〈0.05）. The 3-year local tumor control rates of the three group were 17.4 %,56.5 %, 56,5 %（P 〈 0.05）. The massive hemorrhage of the three group were 4.3 %, 6.5 %, 4.3 %, （P 〉0.05）.Conclusion The 7- day-per-week and the late course accelerated hyperfraction radiotherapy can improve the local tumor control rate and survival rate of stage Ⅲ esophageal cancer.

关 键 词：食管肿瘤 放射疗法 

分 类 号：R735[医药卫生—肿瘤] R730[医药卫生—临床医学]