食管癌TIDC的检测及其临床意义  

Detection of TIDC in esophageal carcinoma tissues and clinical significance

作　　者：张林浩[1] 张羽捷[1] 史天良[2] 张少云[2] 侯二刚[1] 刘兴君[1] 

机构地区：[1]山西省肿瘤医院胸外科,太原030013 [2]山西省肿瘤研究所

出　　处：《肿瘤研究与临床》2007年第1期27-29,共3页Cancer Research and Clinic

基　　金：山西省2005年科技攻关项目（051096-3）

摘　　要：目的探讨肿瘤浸润树突状细胞（TIDC）在食管癌组织与正常食管组织的分布差异，进一步研究TIDC与食管癌患者性别、肿瘤部位、肿瘤大小、浸润程度、临床分期、淋巴结转移等临床特征的关系。方法用流式细胞仪检测51例原发食管癌组织、17例正常食管组织TIDC值。结果食管癌组织TIDC值显著低于正常食管组织，食管癌患者癌组织中TIDC值与临床分期、淋巴转移情况密切相关，而与患者性别、肿瘤大小、病变部位、浸润程度无相关性。结论食管癌组织中TIDC值分布减少是导致机体免疫功能低下，促进肿瘤发展与转移的重要原因之一，检测食管癌组织中TIDC值对判断食管癌生物学行为及预后有一定临床意义。Objective To detect the distribution difference of tumor infiltrating dendritic cells （TIDC） in esophageal carcinoma tissues and normal esophageal tissues, and study the relationship between TIDC and clinical features of esophageal carcinoma patient. Method Fifty one cases of esophageal carcinoma tissues and seventeen normal esophageal tissues were grouped to detect the amount of TIDC respectively by flow eytometry, the result was analyzed. Results The amount of TIDC was less in the esophageal tissues than normal esophageal tissues significantly; Distribution of TIDC in tumor tissues decreased along with the accrescence of TNM stage and the lymph node metastasis, but was not in accordance with the gender of patient, size, site and infiltration degree of the tumors. Conclusions The change of TIDC in the esophageal carcinoma tissues might be one of the important factors leading to the decrease of the immunological function of cells. TIDC could be considered as markers to evaluate the biologic characteristic and prognosis of esophageal carcinoma.

关 键 词：食管肿瘤 树突状细胞 流式细胞术 

分 类 号：R735[医药卫生—肿瘤]