得力生注射液联合化疗治疗老年肺癌的临床观察  

A clinical study on Delisheng combined with chemotherapy in the treatment of aged lung cancer

作　　者：李旭 陈智 郑卫红 彭东崑 

机构地区：[1]贵州省贵阳市第二人民医院肿瘤科,贵州贵阳550000

出　　处：《现代肿瘤医学》2007年第2期200-201,共2页Journal of Modern Oncology

摘　　要：目的观察化疗与得力生注射液联用治疗老年肺癌(治疗组)的临床疗效,并与单用化疗作对比。方法将57例老年肺癌随机分为得力生加化疗组和单纯化疗组(对照组)两组,分别给予相应治疗,观察近期疗效、生活质量、毒副反应。结果治疗组与对照组总有效率分别为46.7%、40.0%(P>0.05)。而治疗组中位缓解期为7个月,对照组中位缓解期为5个月(P<0.05)。两组患者体重和Karnofsky(KPS)评分治疗组治疗后体重和KPS评分比治疗前增加(P<0.05),对照组治疗前后无明显变化(P>0.05)。血液学毒性治疗组白细胞下降II度8例(26.6%)、III度1例(3.3%),对照组II度15例(55.5%)、III度3例(11.1%),两组均无Ⅳ度毒性反应,两组比较差异有显著性(P<0.05);胃肠道反应治疗组II度10例(33.3%)、III度2例(6.0%),对照组II度14例(51.9%),III度6例(22.2%),Ⅳ度2例(7.4%)。两组比较,差异有显著性(P<0.05)。结论得力生注射液对老年肺癌改善临床症状、提高生活质量和减轻化疗副反应均有较好作用。Objective： To evaluate the efficacy and side effect of combined chemotherapy with Delisheng in the treatment of old aged lung cancer. Methods ： Fifty - seven patients with aged lung cancer were divided randomly into control group including 27 patients and therapy group including 30patients. Patients of therapy group was treated by Delisheng and EP; control group only by EP. Results： In therapy group effective rate was 46.7% ;control group was 40.0% , significant difference was not observed between the two groups （P 〉 0.05 ）. For life quality and side effect, significant difference were observed between the two groups（ P 〈 0.05 ）. Conclusion： The combination of Delisheng and EP is effective in improving the quaity of life and side effect for aged patient with lung cancer.

关 键 词：得力生注射液 肺癌 化学治疗 生活质量 

分 类 号：R734.2[医药卫生—肿瘤]