术前区域动脉灌注生长抑素和化疗药物对结肠癌细胞增殖、凋亡和血管形成的影响  

The influence of preoperative regional intra-arterial chemotherapy with somatostatin and chemotherapeutic agents on proliferation, apoptosis and angiogenesis of colorectal carcinoma

作　　者：孙培龙[1] 胡静波 林万隆[3] 叶启发[3] 袁金忠[3] 

机构地区：[1]复旦大学附属上海市公共卫生中心普外科,上海201508 [2]上海市市北医院普外科,上海200443 [3]中南大学湘雅医学院附属三医院,湖南长沙410013

出　　处：《现代肿瘤医学》2007年第2期222-224,共3页Journal of Modern Oncology

基　　金：上海市卫生系统学科带头人培养计划基金(基金编号1999-02)

摘　　要：目的探讨术前区域动脉灌注生长抑素和化疗药物对细胞增殖、凋亡和血管形成的影响。方法结肠癌病人45例,随机分为A、B和C组,每组15例。A组为术前加入善宁的区域动脉灌注化疗组,B组为术前不加入善宁的区域动脉灌注化疗组,C组不采用区域动脉灌注化疗常规手术组。切除标本行MVD、VEGF、Ki67LI、ALI检察。结果A、B、C组MVD分别为12±8、25±17、26±16(P<0.05),VEGF表达分别为39、70、72,Ki67LI分别为8±4、11±6、16±7(P<0.05),ALI分别为4.3±0.5、2.2±0.6、1.5±0.6(P<0.05)。区域动脉灌注化疗对肿瘤增殖有抑制作用,并促进细胞凋亡,加入善宁可以加强上述作用外,对肿瘤血管形成具有抑制作用。结论术前区域动脉灌注化疗药物,可以提高结肠癌的疗效,生长抑素可以增强其抗肿瘤作用。Objective： To evaluate the influence of preoperative regional intra - arterial chemotherapy （PRAC） with somatostatin and chemotherapeutic agents on proliferation, apoptosis and angiogenesis of colorectal carcinoma. Methods： Forty five patients with colorectal carcinoma were randomized into 3 groups, 15 patients in each group： groupz A （PRAC with somatostatin and chemotherapeutic agents） ; group B （PRAC with chemotherapeutic agents only） ; and group C （without PRAC）. The expression of MVD, VEGF, Ki 67 LI and ALl were documented. Results： In 3 groups, MVD were 12 ±8,25 ± 17 and 26 ± 16; VEGF were 39, 70 and 72; Ki 67 LI were 8 ±4.11 ± 6 and 16 ± 7 and ALI were 4,3 ± 0.5,2.2 ±0.6 and 1.5 ± 0.6 , respectively. PRAC with chemotherapeutic agents could inhibit the proliferation and induce apoptosis of tumor, which combined with somatostatin could play synergic effect and inhibit angiogenesis of tumor. Condusion： PRAC with chemotherapeutic agents could improve the therapeutic effect of eolorectal cancer which combined with somatostatin could enhanced its efficacy.

关 键 词：生长抑素 区域动脉灌注化疗(preoperative regional INTRA-ARTERIAL chemotherapy PRAC) 结肠癌 血管形成 细胞凋亡 

分 类 号：R735.37[医药卫生—肿瘤]