上皮性卵巢癌组织中肺耐药蛋白的表达及意义  

Expression and significance of lung resistance protein in epithelial ovarian cancer

作　　者：宋萍萍[1] 王薇[1] 赵安珍[1] 胡友斌[1] 李华[1] 胡玉英[1] 张春梅[1] 

机构地区：[1]三峡大学第一临床医学院(宜昌市中心人民)妇产科,湖北宜昌443003

出　　处：《现代肿瘤医学》2007年第2期231-233,共3页Journal of Modern Oncology

基　　金：宜昌市科技发展计划科研课题项目(K04109)

摘　　要：目的探讨上皮性卵巢癌中肺耐药蛋白(LRP)的表达及其临床意义。方法采用免疫组化SP法及半定量分析方法,检测上皮性卵巢癌64例,复发后二次手术癌组织17例,卵巢良性上皮性肿瘤16例及正常卵巢组织14例中LRP的表达,并进行相关临床病理因素分析。结果在上皮性卵巢癌中LRP的阳性率为78.1%,与卵巢良性肿瘤及正常卵巢有显著性差异(P<0.01);化疗后癌组织中LRP的强阳性表达率与初治卵巢癌组织中相应的表达率差异有显著性。结论LRP在上皮性卵巢癌中较恒定表达,化疗可以增加癌组织中LRP的表达。检测LRP表达水平可以预测卵巢癌对铂类联合化疗疗效,也是判断其预后的可靠指标之一。Objective： To determine the expression and significance of lung resistance protein （LRP） in epithelial ovarian cancer. Methods： The expression of LRP was assayed by means of SP immunohistochemical staining and semi-quantitative technique in 64 cases of epithelial ovarian cancer, in which 17 cases of cancer were recurrent samples ; 16 cases of benign ovarian tumor and 14 normal ovaries. The results were analyzed in correlation with some elinicopathologic parameters. Results： The positive rate of LRP was 78.1% in epithelial ovarian cancer, evaluation of LRP revealed significant differences between the cancer and normal ovaries and benign ovarian tumors ; the positive rate of LRP in cancer tissue from recurrent cancer showed a statistical difference with those in primary ovarian cancer. There was a significant reverse correlation between the expression of LRP and the prognosis of the patients. Conclusion： The expression of LRP could be promoted by platinum based chemotherapy in epithelial ovarian cancer, which may serve as reliable parameters of response to chemotherapy and prognosis.

关 键 词：卵巢癌 肺耐药蛋白 多药耐药 免疫组织化学 

分 类 号：R737.31[医药卫生—肿瘤]