应用生物素标记探针原位检测星形细胞瘤组织中p53基因  

DETECTION OF p53 GENE BY ISOTOPIC PROBE IN ASTROCYTOMA TISSUE

作　　者：郭琳琅[1] 

机构地区：[1]第一军医大学珠江医院

出　　处：《肿瘤研究与临床》1996年第4期236-237,共2页Cancer Research and Clinic

摘　　要：采用核酸分子原位杂交技术检测３２例星形细胞瘤患者瘤组织中ｐ５３基因。结果显示１５例患者瘤细胞中出现ｐ５３基因的杂交颗粒，阳性率为４６．９％。认为约半数的星形细胞瘤的发生与ｐ５３基因有关。The p53 gene were studied in 37 cases of astrocytoma by nucleic acid in situhybridization technique. 15 cases of them got positive results(46.5%).It suggested that inabout 50% of astrocytoma mutation of the suppressor gene,p53 was associated withcarcinogenesis.

关 键 词：星形细胞瘤 肿瘤 抑癌基因 P53基因 生物素探针 

分 类 号：R730.264[医药卫生—肿瘤]