宫颈糜烂与宫颈癌及宫颈上皮内瘤变的关系初探  

Initial Study of the Relationship of Cervical Erosion with Cervical Cancer and Cervical Intraepithelial Neoplasia

作　　者：陆春雪[1] 杜丽敏[1] 张淑兰[1] 姜涛[1] 王伟[1] 

机构地区：[1]中国医科大学附属盛京医院妇产科,辽宁沈阳110004

出　　处：《医学临床研究》2007年第1期20-23,共4页Journal of Clinical Research

基　　金：辽宁省科技攻关资助项目(项目编号:2003225004)

摘　　要：【目的】初步探讨宫颈糜烂与宫颈癌及宫颈上皮内瘤变(CIN)的关系。【方法】随机选取就诊于中国医科大学附属盛京医院宫颈病变诊疗室的患者为研究对象,设无糜烂组、轻度糜烂组、中度糜烂组和重度糜烂组四组,比较各组CIN和宫颈癌的疾病构成比,并作相关因素分析。【结果】各组无病变、CINⅠ、CINⅡ、CINⅢ及宫颈癌的疾病构成比分别为:无糜烂组25.0,36.5%,12.5%,23.1%,2.9%;轻度糜烂组30.4%,40.2%,16.7%,11.8%,1.0%;中度糜烂组37.8%,37.8%,13.3%,10.2%,1.0%;重度糜烂组47.0%,30.0%,11%,9%,3%。其中轻、中、重度糜烂组之间的疾病构成比比较,差异无统计学意义。无糜烂组CIN和宫颈癌的构成比明显高于糜烂组(P<0.01)。【结论】与光滑的宫颈相比,糜烂的宫颈发生CIN和宫颈癌的可能性并未增加。不应该把宫颈糜烂作为宫颈病变的高危因素。对无糜烂的宫颈更应警惕宫颈病变的发生。[Objective]To give initial study of the relationship of cervical erosion with cervical cancer and cervical intraepithelial neoplasia（CIN）. [Methods]For the randomly selected patients in the cervical lesion clinic of the 2nd Affiliated Hospital of China Medical University, four groups were set up as non-erosion group, mild erosion group, moderate erosion group and severe erosion group. Constituent ratios of CIN and cervical cancer of each group were compared and their correlation factors were analysed. [Results]The constituent ratios of no lesions, CIN Ⅰ , CIN Ⅱ , CIN Ⅲ and cervical cancer in each group were： 25%, 36. 5%, 12.5%, 23. 1%, 2.9 % respectively in non-erosion group; 30. 4 %, 40. 2 %, 16.7 %, 11.8 %, 1.0 % respectively in mild erosion group; 37.8%, 37. 8%, 13.3%, 10. 2%, 1.0% respectively in moderate erosion group and 47%, 30%, 11%, 9%, 3 % respectively in severe erosion group. The differences of consitituent ratios among erosion groups were not statistically significant. The constituent ratios of CIN and cervical cancer of non-erosion group were significantly higher than those of erosion groups（ P 〈0.01）. In severe erosion group, the severity of lesion was correlated with age（r= 0. 207, P =0. 039）. [Conclusion]The possibility of CIN and cervical cancer on cervix with erosion is not higher than that on cervix without erosion. Erosion should not be regarded as a risk factor of cervical lesion. Cautions of cervical lesions should be taken more for cervix without erosion.

关 键 词：宫颈糜烂 宫颈肿瘤 宫颈上皮内瘤样病变 

分 类 号：R737.33[医药卫生—肿瘤]