Advances in Phase Detection Technique of Surface Plasmon Resonance Biosensor  

作　　者：Yu Xinglong Wei Xing Deng Yan Liu Fangfang 

机构地区：[1]Dept. of Precision Instruments, Tsinghua University, Beijing 100084, China

出　　处：《稀有金属材料与工程》2006年第A03期299-304,共6页Rare Metal Materials and Engineering

摘　　要：Surface plasmon resonance (SPR) sensing is an optical method based on evanescent wave.SPR biosensor can detect interaction of label-free biomolecules in real-time.With further development,it can become a research instrument in proteomics.SPR biosensor can be divided intensity measurement and phase measurement,and the latter possesses higher sensitivity than the former one.This paper attempts to summarize the SPR phase detection theory,discuss the major developments,compare the merits and deficiencies of various methods,and look forward to future prospects.Surface plasmon resonance （SPR） sensing is an optical method based on evanescent wave. SPR biosensor can detect interaction of label-free biomolecules in real-time. With further development, it can become a research instrument in proteomics. SPR biosensor can be divided intensity measurement and phase measurement, and the latter possesses higher sensitivity than the former one. This paper attempts to summarize the SPR phase detection theory, discuss the major developments, compare the merits and deficiencies of various methods, and look forward to future prospects.

关 键 词：surface plasmon resonance(SPR) phase detection ELLIPSOMETRY HETERODYNE INTERFEROMETRY 

分 类 号：TG[金属学及工艺]