磷脂酰肌醇-3激酶与直肠癌发生发展的相关性研究  

Phosphoinositide-3kinase in rectal carcinoma

作　　者：张国栓[1] 雅健[1] 郑志敏[1] 崔专义[1] 王桂琦[1] 谷敬锋[1] 狄海冰 

机构地区：[1]石家庄市第一医院普外科,河北石家庄050011

出　　处：《中华肿瘤防治杂志》2006年第24期1863-1865,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨磷脂酰肌醇-3激酶(Phosphoinositide-3kinase PI3K)与直肠癌发生及发展的关系,试图进一步探讨直肠癌发生及其转移机制,并为直肠癌的治疗开辟新的途径。方法:流式细胞仪检测PI3K的蛋白表达和直肠癌细胞增殖指数和免疫组化检测PI3K在正常和直肠癌组织中的表达与分布。结果:60例直肠癌组织中有48例增殖指数高于正常组织,差异有统计学意义。60例癌组织中PI3K的蛋白表达均高于正常直肠组织,差异亦有统计学意义。结论:在直肠癌组织中PI3K的蛋白表达和细胞增殖活性均高于正常组织,并且,随着肿瘤恶性程度的增加而逐渐升高,提示PI3K在直肠癌的发生和转移中具有一定的作用。OBJECTIVE： To observed protein expression of PI3K and cell proliferation in rectal carcinoma tissues and investigate the relationship between PI3K and rectal carcinoma using the flow cytomtechnique and immunohistochemistry staining. MEHTORDS： The protein expression of PI3K and the cell proliferation index was detectded with the flow cytometry and Immunohistochemistry staining. RESULTS： The PI3K expression level in sixty tumor tissues was significantly higher than that of the normal tissues. The cell proliferation index in forty-eitht tumor tissues was significantly higher than that of the normal tissues. With the increasing of tumor malignant, the expression of PI3K and the cell proliferation index incereaud. CONCLUSIONS： The expression of PI3K and the cell proliferation index in tumour tissues are both higher than those in normal tissues and increase gradually with the tumour node metastases and Dukes staging.

关 键 词：1-磷脂酰肌醇3-激酶 直肠肿瘤 免疫组织化学 

分 类 号：R735.37[医药卫生—肿瘤]