补气固表制剂对变应性鼻炎鼻黏膜细胞凋亡指数的双向调节作用  

An Experimental Study of Two-ways Regulation of BU QI GU BIAO on the Apoptosis in Nasal Mucosal of Allergic Rhinitis

作　　者：沈啸洪[1] 林文森[1] 

机构地区：[1]天津市南开医院耳鼻喉科,300100

出　　处：《天津医药》2007年第1期44-45,共2页Tianjin Medical Journal

基　　金：天津市应用基础研究计划面上项目(项目编号:05YFMJC12600)

摘　　要：目的:探讨补气固表制剂对变应性鼻炎鼻黏膜细胞凋亡指数的双向调节作用。方法:制作变应性鼻炎豚鼠模型,观察黏膜上皮细胞,黏膜下腺体细胞凋亡指数的变化和细胞凋亡与嗜酸细胞数量的关系,观察黏膜上皮细胞、黏膜下腺体细胞凋亡指数比值对补气固表制剂的反应,并与对照组比较。结果:变应性鼻炎模型组上述指标均异常,与正常对照组相比差异有统计学意义(P<0.01)。补气固表制剂干预后恢复正常,与正常对照组相比差异无统计学意义(P>0.05)。结论:变应性鼻炎鼻黏膜细胞的凋亡具有双重性,其凋亡特性与细胞种类相关,并与嗜酸细胞的数量有关,补气固表制剂能双向调节凋亡指数,保持鼻黏膜的生理稳态,有效地治疗变应性鼻炎。Objective： To investigate the two-way regulating effect of BU QI GU BIAO on the apoptosis figure in nasal mucosal of animals with experimental allergic rhinitis. Methods： The model of allergic rhinitis was experimentally prepared and the apoptosis of deferent nasal tissue of these animals was observed just like the mucosal epithelia and submucous gland cell and the relatioriship between apoptosis and acidophile cells, followed by interfering with BU QI GU BIAO to observe their effects. Results： These figures were abnormal in the Allergic rhinitis group and the difference was statistically significant compared with the control group （P 〈 0.01）, the figures were normal after interventing by BU QI GU BIAO and the difference was not statistically significant （P 〉 0.05） compared with the control group. Conclusion： The nasal mucosal cells of allergic rhinitis are two-regulated, its apoptosis features are related with cell types and quatity of acidophile cells. BU QI GU BIAO can two-regulate the figure of cell apoptosis, protect nasal mucose homeostasis to cure allergic rhinitis effectively.

关 键 词：益气固表 鼻炎 细胞凋亡 黏膜 

分 类 号：R735.2[医药卫生—肿瘤]