血清瘦素质量浓度与胃癌患者营养状态之间的关系  

Relationship between serum leptin concentration and malnutrition in gastric cancer patients

作　　者：张予蜀[1] 袁捷[1] 张振玉[1] 孔超美[1] 杜同信[2] 王自正[2] 

机构地区：[1]南京医科大学附属南京第一医院消化科,江苏南京210006 [2]南京市医学放射免疫检测中心,江苏南京210006

出　　处：《东南大学学报（医学版）》2007年第1期49-51,共3页Journal of Southeast University(Medical Science Edition)

摘　　要：目的:研究血清瘦素质量浓度与胃癌患者营养状态之间的关系。方法:分别测定37例胃癌患者和11例正常对照者血清瘦素以及身高体质量指数(BM I)、血白蛋白(ALB)、肱三头肌皮褶厚度(TSF)、上臂中心肌肉周径(MAC)、理想体质量百分比(NW%)和总淋巴细胞计数(LYM)。胃癌患者分为营养不良(Ⅰ组)和非营养不良(Ⅱ组)两组。结果:血清瘦素质量浓度与BM I、NW%、TSF、MAC呈正相关(P<0.001),而与ALB、LYM无相关性;胃癌组血清瘦素质量浓度Ⅰ组显著低于Ⅱ组及对照组,其中胃癌患者男性与女性血清瘦素质量浓度无差异。结论:胃癌营养不良患者的瘦素质量浓度低于非营养不良者及正常者,临床上可作为营养不良的诊断指标之一。Objective To find the relationship between serum leptin concentration and malnutrition in gastric cancer patients. Methods The serum leptin concentration, body mass index（BMI）, normal weight%, triceps skin-fold thiekness（TSF）, mid-arm circumference （ MAC ）, albumin （ ALB ） and lymphocyte count （ LYM ） of 37 gastric cancer patients and 11 normal control were determined. The gastric cancer patients were divided into malnutrition group （ 14 eases）and non-malnutrition group（23 cases） ;Results The serum leptin concentration of all patients（48 cases） were positively correlated with BMI, NW% ,TSF and MAC （ P 〈 0. 001 ）, not with ALB and LYM ; Serum leptin concentration in malnutrition group were significantly lower than non-malnutrition group and control group, there were no difference between male and female. Conclusion The serum leptin levels in gastric cancer malnutrition are lower than nonmalnutrition and normal group, which can be one of the diagnostic criteria for malnutrition.

关 键 词：胃癌 瘦素 营养不良 

分 类 号：R735.2[医药卫生—肿瘤]