介入联合手术治疗浸润性膀胱癌  

Curative effect analysis of invasive bladder cancer by joint surgical operation with interventional therapy

作　　者：许彪[1] 文斌[1] 刘惕生[1] 韦力谦[1] 

机构地区：[1]广西医科大学第五附属医院放射科介入室,柳州545001

出　　处：《介入放射学杂志》2007年第1期35-38,共4页Journal of Interventional Radiology

基　　金：广西卫生厅医药卫生科研课题(NO.22001080)

摘　　要：目的探讨治疗浸润性膀胱癌的有效方法。方法对40例确诊为浸润性膀胱癌的患者分为A、B两组,每组20例,A组行髂内动脉化疗栓塞和药泵植入联合手术治疗,B组行单纯手术治疗。分析比较两组患者术后复发率、生存率的差异。了解介入联合手术治疗的效果。结果A组患者术前经介入治疗后大部分膀胱肿瘤缩小,血尿缓解或消失,术后切除标本病理检查光镜下可见大片癌细胞变性坏死,间质见炎细胞浸润。A组复发4例(20％),死亡2例(10％)。B组复发9例(45％),死亡4例(20％)。结论髂内动脉化疗栓塞和药泵植入联合手术治疗浸润性膀胱癌,安全有效,能显著提高膀胱癌的疗效。Objective To explore the effective therapy for invasive bladder cancer. Methods Forty patients with invasive bladder cancer were divided into group A and group B. Intra-internal lilac-arterial chemotherapy and infusion pump chemotherapy combined with surgical operation were performed in group A and only surgical operation for group B. The differences of recurrence rates and survival rates between the two groups together with the effectiveness of intra-arterial chemotherapy combined surgical operation were evaluated at the same time. Results Reduction in volumes of cancer and hematuria were obvious and nearly disappeared in group A patients with pathomorphological features demonstrating large pachyareas of necrosis together with degeneration and inflammatory changes of carcinoma tissue; outcoming with five recurrent cases （20%） and 2 deaths （10%）. In group B, 9 cases relapsed（45%） and 4 cases died（20%）, Conclusion The combination of intra-internal lilac-arterial chemoembolization with infusion pump chemotherapy together with surgical operation is safe, effective for invasive bladder cancer, resulting in high raise of survival and life quality.

关 键 词：膀胱肿瘤 动脉灌注 化疗 药泵 外科手术 

分 类 号：R737.14[医药卫生—肿瘤]