介入动脉化疗加放射治疗鼻咽癌的近期疗效  

The study of short-term effect for nasopharyngeal carcinoma with the treatment of radiotherapy after interventional chemotherapy

作　　者：姚宜斌[1] 金玲[1] 胡章明[1] 

机构地区：[1]安徽省铜陵市人民医院放射科,244000

出　　处：《介入放射学杂志》2007年第1期39-41,共3页Journal of Interventional Radiology

摘　　要：目的探讨经颈动脉灌注化疗药物治疗加放疗对鼻咽癌的疗效。方法22例患者经临床(包括鼻咽镜检)、影像学(CT、MR)和病理学检查确诊为鼻咽癌,经颈外动脉介入化疗后加放射治疗。化疗药物为阿霉素(ADM)或吡柔比星、5-氟尿嘧啶(5-FU)和顺铂(DDP)或卡铂(CBP)。同时随机选择同期单纯放疗的25例作为对照,比较其疗效。结果介入组总有效率为100．0％,其中CR为90．9％(20／22),对照组总有效率为100．0％,其中CR为68．0％(17／25),两组分别比较差异有统计学意义(P<0．05)。结论介人动脉化疗后加放射治疗能显著提高鼻咽癌治疗的疗效。Objective To evaluate the clinical curative effect and methods of external carotid artery perfusion treatment plus radiotherapy for nasopharyngeal carcinoma（NPC）. Methods Twenty two patients with nasopharyngeal carcinoma diagnosed by nasopharyngoscopy, CT, MRI were treated by interventional chemotheraphy with riamycin（or epi-adriamycin）, 5-fluorouracil and cisplatin （or carboplatin） and followed by radiotherapy. The control group （25 cases） was randomly selected among the patients of nasopharyngeal carcinoma with radiotherapy in our hospital. Results Of all the patients, the total response rate and CR （complete response） were 100% and 90.9%（20/22） for IC group; and 100% and 68.0%（17/25） for control group respectively （P 〈 0.05）. Conclusion Radiotherapy combined with transcather arterial chemotherapy have synergic effect on patients with nasopharyngeal carcinoma outcoming with high effectiveness.

关 键 词：鼻咽肿瘤 介入治疗 放射治疗 

分 类 号：R739.63[医药卫生—肿瘤]