脑出血患者脑脊液中TNF-α和IL-6与CRP动态变化及β-七叶皂甙钠的影响  

The dynamic changes of TNF-α, IL-6 and CRP in CSF of patients with intracerebral hemorrhage and the effect of Sodium Aescihate

作　　者：王新民[1] 黄远桃[1] 王清勇[1] 杨松林[1] 谭利明[2] 

机构地区：[1]湖南省脑科医院神经内科,湖南长沙410007 [2]中南大学湘雅二医院神经内科

出　　处：《中国医师杂志》2007年第1期7-9,共3页Journal of Chinese Physician

摘　　要：目的观察脑出血（ICH）患者脑脊液中肿瘤坏死因子（TNF-α）、白细胞介素-6（IL-6）、C-反应蛋白（CRP）的动态变化及β-七叶皂甙钠干预作用。方法将符合入选标准的ICH患者随机分为对照组和治疗组各30例，对照组予以常规治疗，治疗组在对照组基础上加用β-七叶皂甙钠。2组分别在病程3d、9d、20d行腰椎穿刺收集脑脊液，同期进行NIHSS评分。结果病程3d2组脑脊液TNF-α、IL-6、CRP水平和NIHSS评分差异无统计学意义（P〉0．05），9d和20d治疗组TNF-α水平和NIHSS评分低于对照组，而IL-6水平高于对照组（P〈0.05）。CRP水平在20d治疗组低于对照组（P〈0.05）。结论ICH急性期脑脊液中TNF-α、IL-6和CRP水平增加，其变化在一定程度上与病情变化和转归有关，β-七叶皂甙钠通过调节TNF-α、IL-6、CRP表达而改善ICH预后。Objective To study the dynamic changes of tumor necrosis factor alpha （TNF-α）, interleukin-6 （ IL-6 ） and C-reactive protein（CRP） in cerebrospinal fluid of patients with inracerebral hemorrhage and the effect of Sodium Aescinate . Methods 60 cases of intracerebral hemorrhage were randomly divided into two groups ： 30 cases of the control group undertaking routine therapy, and 30 cases of the therapeutic group undertaking routine therapy plus Sodium Aescinate. Cerebrospinal fluid was collected on the 3rd, 9th and 20th day of the stroke, and NIHSS was scored at the same time. TNF-α, IL-6 and CRP levels were measured. Results Between the two groups, there was no difference in the levels of TNF-α,IL-6 and CRP, and NIHSS scores on the 3rd day（ P 〉0. 05 ）. The level of TNF-α in the therapeutic group was Iower compared to that in control group on the 9th and 20th day. The level of CRP was lower in the therapeutic group only on the 20th day. However, NIHSS scores and interleukin-6 level were higher in the therapeutic group. Conclusion The levels of TNF-α, IL-6 and CRP in cerebrospinal fluid increased in acute phase of intracerebral hemorrhage. The dynamic changes of them were in consistent with the stroke severity. Sodium Aescinate administration could improve the neural function by affecting the inflammation reactions.

关 键 词：脑出血/治疗 七叶素/治疗应用 肿瘤坏死因子Α 白细胞介素6 C反应蛋白质 

分 类 号：R74[医药卫生—神经病学与精神病学]