大萼香茶菜中的新二萜化合物  

New Diterpenoid Compound from Rabdosia macrocalyx

作　　者：石浩[1] 何山[1] 何兰[2] 潘远江[1] 

机构地区：[1]浙江大学化学系,杭州310027 [2]北京师范大学化学系,北京100085

出　　处：《高等学校化学学报》2007年第1期100-102,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20472073);浙江省自然科学基金(批准号:Y404357)资助

摘　　要：On the basis of the investigation on natural product antitumor agents,a new diterpenoid named macrocalyxin J was isolated from the leaves of Rabdosia macrocalyx（Dunn） Hara by silica gel column chromatography.Based on IR,MS,1H NMR,13C NMR and 2D NMR spectroscopies,the structure of macrocalyxin J was determined as（1α,6β,11β,14α）-1,7∶6,20-diepoxy-6,11-dihydroxy-6,7-seco-ent-kaur-16-ene-7,15-dione-14-acetate.The antitumor activity of the compound was assayed by MTT method.Macrocalyxin J was shown to have a potency in vitro against the cultures of Hela cells.On the basis of the investigation on natural product antitumor agents, a new diterpenoid named macrocalyxin J was isolated from the leaves of Rabdosia macrocalyx（Dunn） Hara by silica gel column chromatography. Based on IR, MS, 1H NMR, 13C NMR and 2D NMR spectroscopies, the structure of macrocalyxin J was determined as （ 1 α, 6β, 11β, 14α ） -1,7： 6,20-diepoxy-6,11 -dihydroxy-6,7-seco-ent-kaur-16-ene-7,15 - dione-14-acetate. The antitumor activity of the compound was assayed by MTT method. Macrocalyxin J was shown to have a potency in vitro against the cultures of Hela cells.

关 键 词：大萼香茶菜 B断裂贝壳杉烯 大萼香茶菜癸素 

分 类 号：O629.61[理学—有机化学]