根除幽门螺杆菌对功能性消化不良的影响  

Influence of Helicobacter pylori eradication on functional dyspepsia

作　　者：王建荣[1] 

机构地区：[1]江苏省泰州市第四人民医院消化科,225300

出　　处：《中国医师进修杂志》2007年第1期13-15,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨根除幽门螺杆菌（Hp）对Hp阳性的功能性消化不良（FD）患者症状的影响。方法191例胃镜检查Hp阳性的FD患者随机分为两组：治疗组予以抗H_p三联（奥美拉唑20mg，阿莫西林1000mg，克拉霉素500mg）治疗1周及莫沙必利5mg，每日3次，治疗2周；对照组予以奥美拉唑20mg，每日2次治疗1周及莫沙必利5mg，每日3次，治疗2周。停药4周后行^14C-尿素呼气试验检测，同时观察Hp根除与否对患者症状改善的影响。结果治疗组Hp根除率为79．0％，Hp阳性的FD患者在根除Hp后症状积分改善显效率达38．7％，明显高于Hp根除失败亚组的15．0％（P〈0．01），亦明显高于对照组的12．5％（P〈0．01），但各类型的FD症状积分改善显效率差异无统计学意义。结论部分Hp阳性的FD患者根除Hp后症状可明显改善。Objective To investigate the influence of Helicobacter pylori （Hp）eradication on the symptoms of Hp positive patients with functional dyspepsia （FD）. Methods One hundred and ninety-one FD patients with Hp infection receiving gastroendoscopy were randomly allocated into two groups：the treatment group （31 ulcer-like dyspepsia, 30 dysmotifity-like dyspepsia, 34 non-specific dyspepsia）were treated with anti-Hp triple therapy（omeprazole 20 mg, amoxil 1000 mg, clarithromycin 500 mg）for one week and mosapride 5 mg third daily for two weeks, but those in the control group （30 ulcer-like dyspepsia, 31 dyismotility-like dyspepsia, 35 non-specific dyspepsia）were treated with omeprazole 20 mg twice daily for one week and mosapride 5 mg third daily for two weeks. The status of Hp infection was determined by ^14C-UBT at 4 weeks （both treatment group and control group）, symptom scores in the two groups were compared. Results The rate of Hp eradication was 79.0% in the treatment group. Of 38.7% patients with successful Hp eradication in the treatment group had a good symptomatic response after the triple therapy respectively, higher than those from the patients who failed Hp eradication （ 15.0%, P 〈 0.01 ）and those from the control group （ 12.5%, P 〈 0.01 ）, but no significant difference was found between ulcer-like dyspepsia, dysmotifity-like dyspepsia and non-specific dyspepsia （ulcer-like dyspepsia 40.0%, dysmotifity-like dyspepsia 39.1%, non-specific dyspepsia 37.0%, P〉 0.05）. Conclusion A certain subset Hp-positive functional dyspepsia patients, symptoms can be obviously improved after treatment by Hp eradication.

关 键 词：功能性消化不良 根除幽门螺杆菌 幽门螺杆菌感染 症状 

分 类 号：R573[医药卫生—消化系统]