L-精氨酸防治胎儿宫内发育迟缓的疗效和机制  

Therapeutic effect and mechanism of L-Arginine on intrauterine growth retardation

作　　者：帅春[1] 汪灏[2] 肖昕[3] 熊爱华[4] 

机构地区：[1]广东省妇幼保健院儿科,广州510000 [2]广州市第一人民医院,广州510000 [3]暨南大学第一附属医院,广州510000 [4]暨南大学医学院,广州510000

出　　处：《实用药物与临床》2007年第1期16-18,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨L-精氮酸（L-Arginine，L—Arg）防治胎儿宫内发育迟缓的疗效。并阐明其治疗机理。方法被动吸烟法建立IUGR孕鼠模型。20只IUGR孕鼠随机分为非干预组和干预组，另选10只孕鼠作为正常对照组。在IUGR孕鼠妊娠的第7～20天给予干预组L．精氮酸。第21天处死孕鼠，测定胎仔体重。鼻一臀长和重量系数，分别测定妊娠末期孕鼠血中NO、ET-1含量和尿液中8-epi-PGF2a的含量。结果干预组胎仔的体重明显增加（P〈0．01），孕鼠血清NO水平明显升高（P〈0．01），血浆ET-1明显降低（P〈0．01），NO／ET-1明显升高（P〈0．01），尿液中8-epi—PGF2a的含量明显降低（P〈0．01）。结论L—Arg能调节IUGR孕鼠体内NO／ET-1失衡，改善胎盘．子宫．胎儿的血供，减轻其体内的脂质过氧化作用，对IUGR具有较好的干预效果。Objective To discuss the therapeutic effect and mechanism of L-Arginine on intrauterine growth retardation according to the determination and analysis of serum nitric oxide, plasma endothelin-1 and urine 8-epi- prostaglandin F2a. Methods Pregnant rat model with IUGR was established using passive smoking method. Twenty pregnant rats with IUGR were randomized into two groups： Non-intervention group and intervention group. In addition, ten normal pregnant rats were selected into control group. Rats were administered by L-Arginine during 7 - 20 d pregnancy in intervention group. Pregnant rats were killed on the 21st day of pregnancy. The weight, nuse-hip-length and poundera index of these fetal rats were measured. Serum nitric oxide, plasma endothelin-1 and urine 8-epi-prostaglandin F2a. of pregnant rats were measured respectively. Results In intervention group, fetal weight was obviously increased （ P 〈 0.01 ）, Serum nitric oxide and NO/ET-1 in pregnant rats were apparently increased （ P 〈 0.01 ）, plasma endothelin- 1 and urine 8-epi-prostaglandin F2a. in pregnant rats were apparently decreased （ P 〈 0.01 ）. Conclusion L-Arginine has good therapeutic effect on IUGR, and it can regulate NO/ET-1 balance, increase piacenta-uterus-fetus blood supply, and inhibit lipid peroxidation.

关 键 词：L-精氨酸 胎儿宫内发育迟缓 孕鼠 NO ET-1 8-表氧-前列腺素F2a 

分 类 号：R96[医药卫生—药理学]