甲状腺转录因子1在肺癌患者胸水中的诊断价值  

Diagnostic value of thyroid transcription factor 1 in pleural fluid of patients with lung cancer

作　　者：蒋冰（综述）[1] 吴广平（审校）[1] 

机构地区：[1]中国医科大学附属第一医院病理诊断中心,沈阳 110001

出　　处：《国际肿瘤学杂志》2007年第1期41-44,共4页Journal of International Oncology

基　　金：辽宁省教育厅科研基金资助项目（2004D164）

摘　　要：胸水是肺部多种疾病的常见并发症，其中绝大多数恶性胸水是由肺腺癌引起。常规细胞学检查主要根据细胞形态进行诊断，由于腺癌细胞与反应性间皮细胞形态极为相似，故鉴别以上两种细胞是诊断恶性胸水的最大难点。甲状腺转录因子1（TTF-1）特异表达于肺腺癌、小细胞肺癌和甲状腺癌，在排除极少发生甲状腺癌的前提下，通过检测TTF-1既有助于诊断肺癌性胸水，又可区分肿瘤的来源是原发于肺还是继发于肺，以此为临床治疗提供新靶点。Pleural effusions are common complications that may be produced by a wide variety of lung diseases. Most of malignant pleural effusions are due to adenocarcinoma of lung. Conventional cytologic diagnosis is based on cytomorphology, however, as cells of adenocarcinoma and reactive mesothelial proliferation are extremely similar in morphology, the distinction between these two entities may be the most vexing problem in the diagnosis of malignant pleural effusions. Thyroid transcription factor 1 （ TTF- 1 ） is expressed in adenocarcinoma of lung,small cell lung carcinoma and thyroid neoplasm specifically. Thus,TTF-1 is useful in the diagnosis of pleural effusions of lung cancer, as well as the discrimination of the origin of pulmonary neoplasm as to whether it is primary or not ,provided that the possibility of primary thyroid has been excluded, by which it can provide new target for the clinical treatment.

关 键 词：肺肿瘤 转录因子 肿瘤标记 生物学 胸水 细胞诊断学 

分 类 号：R730.4[医药卫生—肿瘤] R734.2[医药卫生—临床医学]