抑郁症患者与健康人血浆孤啡肽含量的初步研究  

A Controlled Study on Orphanin FQ in the Patients with Depression and Healthy Volunteers

作　　者：郑洪波[1] 王斌[1] 张璐璐[1] 泰峰[1] 胡文生[1] 黎娟花[1] 

机构地区：[1]广州市精神病医院,广东广州510370

出　　处：《国际医药卫生导报》2007年第1期4-6,共3页International Medicine and Health Guidance News

基　　金：课题项目：广东省卫生厅（A2006550）广州市卫生局（2005YB100）

摘　　要：目的为探讨抑郁症的可能病因，对抑郁症患者与健康人血浆孤啡肽含量进行了初步研究。方法抽取29例抑郁症患者和24例健康人的静脉血，用放射免疫（RIA）的方法分别测其血浆中OFQ含量，比较抑郁症患者和健康人血浆OFQ含量的差异，抑郁症OFQ含量与HAMD评分的相关性，及对抑郁症患者血浆OFQ含量的影响因素。结果与健康人比较，抑郁症组OFQ含量明显升高（t=8．70，P〈0．01），OFQ含量与HAMD评分呈正相关（r=0．63；P〈0．01），影响OFQ含量的主要因素有抑郁情绪、夸大、失眠、自卑感、自杀，强迫症状，教育水平、关注身体健康等因素，而年龄、性别、职业、病程、曾用药等其他因素对OFQ含量的影响较小。结论抑郁症患者血浆OFQ含量明显高于健康人，可作为抑郁症评估的参考指标。Objective To investigate the impossible pathogeny of depression through studying the relation between orphanin FQ .and depression, Methods The level of plasma OFQ of 29 patients with depression （depression group）and 24 healthy person（controlled group） were measured by radioimmunoassay （RIA） respectively. Results The level of plasma OFQ in the depression group was statistically higher than that of the controlled group （t=8.70, P〈0. O1）. The level of OFQ was positively correlated to HAMD（r=0. 63,P〈0. 01）. Many factors affected the OFQ level, including gloomy, exaggeration, insomnia, education, etc. While other factors like age, sex, occupation do few effect to it. Conclusions There is the possibility that the level of plasma OFQ can be used to diagnose depression.

关 键 词：孤啡肽 抑郁症 

分 类 号：R74[医药卫生—神经病学与精神病学]