肺癌表遗传学研究进展  

Research progress on epigenetics of lung cancer

作　　者：汪亚松[1] 金永堂[1] 

机构地区：[1]安徽医科大学公共卫生学院,合肥230032

出　　处：《卫生研究》2007年第1期109-111,共3页Journal of Hygiene Research

基　　金：国家自然科学基金资助项目(No.30471427)

摘　　要：表遗传学机制在肺癌的形成中占据重要地位,包括DNA的甲基化和组蛋白修饰,肺癌中与癌形成有关基因的失活多与异常甲基化有关,并且组蛋白修饰和甲基化紧密联系着。表遗传学改变多发生在肺癌早期,使得它成为肺癌化学预防的优良指标,了解肺癌表遗传现象的机制及其与传统遗传学的相互作用关系将有利于发现安全、高效的化学预防药物。Epigenetic events, a key driving force in the development of lung cancer, two changes integral to epigenetic transcriptional control are DNA methylation and covalent modification of histone proteins. Aberrant methylation may be the most common mechanism of inactivating cancer-related genes in lung cancer, and histone modification may be closely associated with DNA methylation. It was seemed that epigenetic changes could be of the earliest events observed during cancer development, making them excellent targets for chemoprevention. Understanding the mechanisms involved in epigenetic regulation and how they interact with genetic changes during lung cancer progression could facilitate development of newer, more efficacious, and safer chemopreventive agents.

关 键 词：表遗传学 甲基化 组蛋白修饰 肺癌 

分 类 号：R734.2[医药卫生—肿瘤] Q354[医药卫生—临床医学]